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Stranica 1 iz 61 rezultatima
Sodium Benzoate Attenuates Secondary Brain Injury by Inhibiting Neuronal Apoptosis and Reducing Mitochondria-Mediated Oxidative Stress in a Rat Model of Intracerebral Hemorrhage: Possible Involvement of DJ-1/Akt/IKK/NFκB Pathway.
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Intracerebral hemorrhage (ICH) is a devastating disease with high rates of mortality and morbidity. The aim of this study was to explore whether Sodium Benzoate (NaB) could reduce neural cell apoptosis and alleviate neurological deficits after ICH. To assess the therapeutic effects of NaB, first, we
2-(2-Fluorobenzamido)benzoate ethyl ester (EFB-1) inhibits superoxide production by human neutrophils and attenuates hemorrhagic shock-induced organ dysfunction in rats.
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Neutrophil activation after trauma-hemorrhagic shock (T/H) has been implicated in the development of multiple organ dysfunction (MOD). In this study, we report that a small chemical compound, 2-(2-fluorobenzamido)benzoic acid ethyl ester (EFB-1), exhibited a potent inhibitory effect on the
Effects of estradiol benzoate and their modification by bleeding; studies on the skeleton and the blood calcium of the cockerel.
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[Hemorrhagic action of strong doses of estradiol benzoate; experimental studies in dogs].
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Effects of estradiol treatment and/or ovariectomy on spontaneous hemorrhagic lesions in the pancreatic islets of Sprague-Dawley rats.
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The present study was conducted to investigate the effect of estradiol treatment and/or ovariectomy (OVX) on non-neoplastic lesions in the pancreatic islets of Sprague-Dawley rats. Males were divided into non-treatment (naïve) and beta-estradiol 3-benzoate (EB) treatment groups and females into
Effects of postovulatory estradiol benzoate administration on women's ovarian function.
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The effects of postovulatory estradiol benzoate (EB) administration were studied in six women having normal biphasic, presumably ovulatory, menstrual cycles. EB was administered intramuscularly at dose levels of 0.5 and 10 mg daily for 5 consecutive days. The study covered a total of 30 cycles;
Effect of a sodium benzoate-sodium bicarbonate compound on dental plaque formation.
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The objective of this study was to evaluate the effect of a sodium benzoate-sodium bicarbonate (SBSB) compound on dental plaque formation and developing gingivitis. Eighteen subjects were given a prophylaxis and instruction in oral hygiene to establish plaque-free conditions and gingival health for
The positive feedback of estradiol on gonadotropin secretion in women with perimenopausal dysfunctional uterine bleeding.
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The functionality of the hypothalamic-pituitary-ovarian axis was explored in 27 women with perimenopausal dysfunctional uterine bleeding. The positive feedback effect of estradiol on LH and FSH was studied by the estrogen challenge test, which was performed by a single i.m. injection of estradiol
[Clinical value of adjuvant therapy with estrogen for postpartum hemorrhage].
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OBJECTIVE
To investigate the clinical efficacy of estrogen in management of postpartum hemorrhage due to uterine atony.
METHODS
Totalling 112 puerperants with postpartum hemorrhage due to uterine atony were randomly assigned into 2 groups and received routine managements for uterine atony such as
Pharmacokinetics, biodistribution and toxicology following intravenous and oral administration of DSM-RX78 and EFB-1, two new 2-(2-fluorobenzamido)benzoate-based PDE4 inhibitors, to rats.
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OBJECTIVE
The aim of this study was to determine the pharmacokinetic profile, biodistribution and toxicity of ethyl 2-(2-fluorobenzamido)benzoate (EFB-1) and methyl 2-(2-fluorobenzamido)benzoate (DSM-RX 78), two phosphodiesterase IV inhibitors, which potently attenuate haemorrhagic shock-induced
Roles of histamine receptors and oxyradicals in aggravation of acid-induced gastric haemorrhagic ulcers in endotoxaemic rats.
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We clarified the roles of histamine H(1)-, H(2)-, H(3)-receptors and oxyradicals in the exacerbation of acid-induced gastric haemorrhage and stomach ulcer in endotoxaemic rats by measuring changes in gastric mucosal glutathione concentrations, lipid peroxide generation and histamine levels as well
Teratogenic effects of long term consumption of potassium benzoate on eye development in BALB/c fetal mice.
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OBJECTIVE
Potassium benzoate (PB) is used as a substitute preservative for sodium benzoate primarily in dietetic foods where the sodium content is minimized. There are few reports about the teratogenic effects of PB. The purpose of this study is to investigate the teratogenic effects of PB on eye
Teratogenic effects of long term consumption of potassium benzoate on eye development in BALB/c fetal mice.
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OBJECTIVE
Potassium benzoate (PB) is used as a substitute preservative for sodium benzoate primarily in dietetic foods where the sodium content is minimized. There are few reports about the teratogenic effects of PB. The purpose of this study is to investigate the teratogenic effects of PB on eye
Inhibitory effects of benzyl benzoate and its derivatives on angiotensin II-induced hypertension.
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Hypertension is a lifestyle-related disease which often leads to serious conditions such as heart disease and cerebral hemorrhage. Angiotensin II (Ang II) plays an important role in regulating cardiovascular homeostasis. Consequently, antagonists that block the interaction of Ang II with its
Upregulation of estrogen receptor alpha and mediation of 17beta-estradiol vasoprotective effects via estrogen receptor alpha in basilar arteries in rats after experimental subarachnoid hemorrhage.
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OBJECTIVE
The authors previously demonstrated that 17beta-estradiol benzoate (E2) treatment prevents subarachnoid hemorrhage (SAH)-induced cerebral vasospasm and preserves endothelial nitric oxide synthase (eNOS) in male rats. Changes in the expression of estrogen receptor (ER) subtypes ERalpha and
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