Determine if the immunogenicity of oral typhoid can be enhanced in children by introducing zinc supplementation: Our recent studies on the interactions of oral cholera vaccine with breast milk and zinc provide some basis for improving immunogenicity, but additional work is needed to improve many of the oral vaccines. In this study we also plan to evaluate if the immune response to Cholera and Vivotif can be enhanced by supplementation with zinc using methods described earlier. We would like to study children, 2-5 years of age for this purpose.

There is a high burden of enteric parasites in the gut of people living in densely populated areas of less developed countries. The effect of concurrent parasitic infestations on immune responses has not been studied widely, although it is an area of utmost importance for natural protection as well as vaccine immuno-prophylaxis. In this study we plan to determine the impact of pretreatment with antiparasitic agents (albendazole and secnidazole) on the immunogenicity of the oral cholera and typhoid vaccines in children, 2-5 years of age

In this study, we aim to evaluate if immunogenicity of the oral cholera vaccine is modified in children living in a high arsenic contaminated area in Bangladesh. The plan is to study children 2-5 year old living in Shahrasti thana near Matlab where the tubewell water is highly contaminated with arsenic and this study will not be randomized double-blind, and compare their responses with responses of age matched children living in arsenic free area, such as in Mirpur area of Dhaka city. We only plan to study the effect of Dukoral vaccinees since this vaccine has been widely studied in Bangladesh. If an impact of arsenic is seen on immune response to this vaccine, future studies could be done with other vaccines including Vivotif.

Cholera

Typhoid

Placebo will be given according to randomization list

Placebo

Control will be selected from the Arsenic non contaminated Area

Control

Zinc Sulphate will be given according to randomization list

Zinc Sulphate

Albendazole and Secnidazole will be given according to randomization list

Albendazole and Secnidazole

Participant will be selected from the Arsenic Contaminated Area

Arsenic

Firdausi Qadri

Studies of Immune Responses to Orally Administered Vaccines in Developing Country

Studies of Acute and Memory Immune Responses to Orally Administered Vaccines in Developing Country Children and Factors That May Augment Such Responses

Dr. Firdausi Qadri

International Centre for Diarrhoeal Disease Research, Bangladesh

Göteborg University

Carnitine Palmitoyltransferase II Deficiency

Very Long Chain Acyl Coa Dehydrogenase Deficiency

Bezafibrate

Neuromusculare Research Unit, Rigshospitalet

Effect of Bezafibrate on Muscle Metabolism in Patients With Fatty Acid Oxidation Defects

Evaluation of the Effect of Bezafibrate on Muscle Metabolism During Exercise in Patients With CPTII and VLCAD Deficiency

Mette Cathrine Oerngreen

Rigshospitalet, Denmark

Groupe Hospitalier Pitie-Salpetriere

300 mg of testosterone enanthate by intramuscular injection once weekly for 16 weeks

Placebo (sesame oil) by intramuscular injection once weekly for 16 weeks

HIV Associate Weight Loss

Testosterone enanthate

Charles R. Drew University

Testosterone and Physical Function in HIV+ Men

Testosterone and Physical Function in HIV Associate Weight Loss

A modification of the Margaria stair climb was used to assess stair-climbing power. participants were instructed to ascend a 12-step staircase as rapidly as possible, with ascent time recorded over the middle four steps (0.66 m) of the climb.

Participants were instructed to walk a 160-m flat course as fast as possible without running. Photoelectric cells and timers were used to determine time to the nearest 0.01 s. The faster of two trials was used to calculate walking speed (m/s).

To simulate daily activities such as carrying groceries or suitcases, participants carried a load equal to 20% of their body weight while walking a distance of 20 m as fast as possible on a flat course.

citric acid/groznica

Studies of Immune Responses to Orally Administered Vaccines in Developing Country

Effect of Bezafibrate on Muscle Metabolism in Patients With Fatty Acid Oxidation Defects

Testosterone and Physical Function in HIV+ Men

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