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colorectal neoplasms/bazga
Veza se sprema u međuspremnik
5 rezultatima
Associated expression of α2,3sialylated type 2 chain structures with lymph node metastasis in distal colorectal cancer.
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OBJECTIVE
One of the typical modifications on the surface of cancer cells is sialylation of terminal carbohydrates. The expression of several types of sialylation of glycoconjugates was investigated in colorectal cancer.
METHODS
The cancer tissue specimens obtained from 65 colorectal cancer patients
Alpha 2,6 sialylation of N-acetyllactosaminic sequences in human colorectal cancer cell lines. Relationship with non-adherent growth.
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In a previous work we found that human colorectal cancer tissues express increased levels of an alpha 2,6 sialyltransferase (alpha 2,6 ST) acting on N-acetyllactosaminic sequences (E.C. 2.4.99.1). In this study we have taken advantage of the known specificity of elderberry bark lectin (Sambucus
Sialoglycoconjugate expression in primary colorectal cancer and metastatic lymph node tissues.
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OBJECTIVE
Aberrant cell surface glycosylation, and especially excessive sialylation, is thought to have great importance in tumor malignancy. To investigate the clinicopathological significance of sialylation in colorectal cancer, we performed histochemical analyses using sialic acid-binding
Lectin Histochemistry Shows WGA, PHA-L and HPA Binding Increases During Progression of Human Colorectal Cancer.
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OBJECTIVE
Most colorectal carcinomas develop from an adenoma-carcinoma sequence to metastatic disease. The aim of the present study was to use lectins, carbohydrate-binding proteins, to detect changes in glycosylation during this malignant progression.
METHODS
Sections from normal colorectal mucosa,
Immunohistochemical analysis of sialic acid and fucose composition in human colorectal adenocarcinoma.
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The expression of different sialoglycoconjugates and fucoglycoconjugates in normal mucosa and adenocarcinoma samples from 43 colorectal cancer patients was investigated by using specific lectins and applying a semiquantitative analysis. A pronounced decrease in the intracellular binding of the
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