Group 1 (n=50): women (age 20-40year) with PCOS who are diagnosed according to the criteria of the Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2003), which require two of the following 3 manifestations:
oligo- or anovulation,
clinical and/or biochemical signs of hyperandrogenism (> 2.08 nmol/l),
polycystic ovaries on ultrasound examination (the presence of ≥12 follicles measuring 2-9 mm in diameter and/or ovarian volume > 10 cm)

Group 2 (n=50): women (age 20-40 year) with male factor infertility.

Follicular fluid and granulosa cell collection

Polycystic Ovary Syndrome

RNA extraction and RT-qPCR Protein extraction and western blotting ELISA assay

qRTPCR (mRNA level).

IVF Outcome in Polycystic Ovary Syndrome Patients

Identification of Recent Biomarkers in Polycystic Ovary Syndrome Patients as a Predictors of IVF Outcome

Detect difference in expression of phoenixin and humanin markers in follicular fluid and their role in pathogenesis of PCOS.

Assess the link between phoenixin and humanin through the PI3/AKT/mTOR and autophagy signalling pathway that may be considered as a future therapeutic target in PCOS patients to improve IVF outcome.

Engy Mohamed Fikry

Assistant Lecture

Assiut University

Morphine group (n=700), where patients will be treated with i.v. injection of Morphine 2,5 mg diluted in 10 ml of NaCl 0,9%. The treatment will be given during CPR as soon as possible.

Ketamine group (n=700), where patients will be treated with i.v. injection of Ketamine 50 mg diluted in 10 ml of NaCl 0,9%. The treatment will be given during CPR as soon as possible.

Control group (n=700), where patients will be treated with i.v. 10 ml of NaCl 0,9%. The treatment will be given during CPR as soon as possible.

Cardiac Arrest

Adult patients with an out-of-hospital cardiac arrest will be evaluated by skilled paramedics or prehospital trained anaesthesiologists for inclusions criteria to the study and randomised to get the blinded study medicine as addition to standard treatment of cardiac arrest. Randomization will be performed by means of sealed envelopes containing number of syringe that will be used.

Morphine

Ketamine Injectable Solution

Saline 0.9%

Morphine or/and Ketamine in Out-of-hospital Cardiac Arrest

Treatment of Patients With Morphine or/and Ketamine During Out-of-hospital Cardiac Pulmonary Resuscitation

Survival rate at 30 days in patients after out-ofhospital cardiac arrest treated or not with Morphine or ketamine during CPR

Measurement of biochemical markers of brain damage (NSE, S-100B protein) at 2,12, 24 and 48 hours in patients after out-of-hospital cardiac arrest.

Registration of length of patients stay (days) in the intensive care units

Registration of patients stay (days) in the hospitals

Registration of survival rate at 3 months after cardiac arrest

Modified Rankin Scale (mRS) will be used for evaluation of neurological outcome. The mRS-9Q Survey and web calculator / error-checker can be accessed freely at:
www.modifiedrankin.com. The mRS score encodes meaningful levels of function from no symptoms or functional impairment (mRS score = 0) through to severe disability requiring constant nursing care (mRS score = 5). the mRS-9Q is an easy-to-use tool to determine the mRS score with very good interobserver reliability and reproducibility. Web-based calculator can be also administered by personnel without clinical training, either in person or by telephone.

Vladimir Kuklin

Head of day case surgery unit

University Hospital, Akershus

Adult patients who have sustained an out-of-hospital cardiac arrest for which advanced life support will be provided by skilled paramedics or prehospital trained anaesthesiologists will be eligible for inclusion.

Every ambulance car or helicopter on duty in the city of Oslo and Vestre Viken Hospital Trust will have a trial pack containing 10 pre-filled 10 ml syringes that will be labeled with only randomisation number. Paramedics or prehospital trained anaesthesiologists will not know the content of the syringes as well as a meaning of the randomisation number. The pharmacy of Akershus university hospital will be responsible to prepare the syringes.

cytochrome c/hypoxia

IVF Outcome in Polycystic Ovary Syndrome Patients

Morphine or/and Ketamine in Out-of-hospital Cardiac Arrest

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