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Comparison of hemodynamic effects induced by pentaformilgitoxin and deslanoside in patients with heart failure.

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The effect of pentaformilgitoxin and deslanoside on heart rate, blood pressure and cardiac output was compared in six patients with heart failure. Pentaformilgitoxin caused an increase of cardiac output from 3361 ml/min to 4183 ml/min (p less than 0.01). Deslanoside induced a non significant

Altered vagal and sympathetic control of heart rate in left ventricular dysfunction and heart failure.

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We investigated alterations in autonomic control of heart rate in conscious dogs with left ventricular (LV) dysfunction in the presence and absence of heart failure (HF) due to rapid pacing. In dogs with LV dysfunction but no HF, indexes of parasympathetic control decreased significantly after only

Effect of metildigoxin (beta-methyldigoxin) on congestive heart failure as evaluated by multiclinical double blind study.

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The efficacy on congestive heart failure of metildigoxin (beta-methyldigoxin, MD), a derivative of digoxin (DX), which had a good absorption rate from digestive tract, was examined in a double blind study using a gorup comparison method. After achieving digitalization with oral MD or intravenous

Successful resuscitation of serious bupivacaine intoxication in a patient with pre-existing heart failure.

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OBJECTIVE In dogs intoxicated with bupivacaine, clonidine is effective to treat conduction disturbances and dobutamine corrects myocardial depression. We report the case of a patient who experienced severe bupivacaine cardiotoxicity and who was treated successfully using these

Effect of digitalis on norepinephrine kinetics in congestive heart failure.

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OBJECTIVE The aim of this study was to test the hypothesis that digitalis glycosides would reduce sympathetic activity as reflected by forearm venous norepinephrine kinetics in patients with congestive heart failure. BACKGROUND Digitalis glycosides have been reported to decrease sympathetic nervous

Digitalis increases brain natriuretic peptide in patients with severe congestive heart failure.

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Ouabain can cause increased secretion of atrial natriuretic peptide (ANP) from atrial cardiocyte culture, but the effects of digitalis in a therapeutic range on the secretion of cardiac natriuretic peptide including ANP and brain natriuretic peptide (BNP), mainly from the ventricle, in patients with

Pharmacokinetics and serum concentration--effect relationship of intravenous deslanoside.

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The antibodies of two commercially available digoxin-radioimmunoassay kits showed complete equimolar cross-reactivity with deslanoside and were used to determine serum levels of the latter glycoside. The serum concentrations of deslanoside were measured after a single intravenous dose of 1.2 mg in

Are contraction and relaxation coupled in patients with and without congestive heart failure?

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BACKGROUND Although changes in contractility are often accompanied by changes in relaxation, a mathematical model of ventricular coupling has not been described. A model we examined suggests a hyperbolic relation between measurements of contraction and relaxation. We thus tested the hypothesis that

[Effects of cardiac support on delayed resuscitation in extensively burned patients with shock].

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Objective: To explore the effects of cardiac support on delayed resuscitation in extensively burned patients with shock. Methods: Clinical data of 62 extensively burned patients with shock on admission, admitted to the 159th Hospital of PLA (hereinafter referred to as our hospital) from January 2012

Simultaneous analysis of cardiac glycosides in blood and urine by thermoresponsive LC-MS-MS.

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A new thermoresponsive polymer separation column was applied to simultaneous analysis of four cardiac glycosides (CGs) being widely used for the treatment of arrhythmias and heart failure in human blood and urine. This column is composed of an N-isopropylacrylamide polymer, the surface of which

Cardioactive Steroid Toxicity

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Cardioactive steroids (CAS) are medically important compounds historically used for conditions like edema and "dropsy." There is literature from the 17th century regarding their therapeutic effects. They are available in several plants including oleander, foxglove, lily of the valley, red squill,

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