diabetes mellitus/hypoxia

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Effect of hypoxia on metabolism and contractile function of the heart in rats with type 2 diabetes mellitus and abdominal obesity.

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Type 2 diabetes mellitus was modeled in newborn albino rat pups. Metabolism and contractile activity of isolated heart under conditions of hypoxia were studied on adult rats. Contractile activity of the myocardium in animals with type 2 diabetes mellitus and abdominal obesity decreased during

Hypoxemia and glycemic control in type 2 diabetes mellitus with extreme obesity.

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BACKGROUND Obstructive sleep apnea (OSA) has been shown to be associated with type 2 diabetes mellitus (DM). Studies on healthy individuals found that OSA is associated with lower insulin sensitivity. We hypothesized that nocturnal hypoxemia from OSA is associated with poorer glycemia in severely

An evaluation of iodine-123 iodoazomycinarabinoside as a marker of localized tissue hypoxia in patients with diabetes mellitus.

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Peripheral vascular disease is a serious and common complication in patients with diabetes mellitus (DM). Evaluation is, conventionally, by transcutaneous oxygen tension measurements (TcpO2), although this technique has some limitations in the evaluation of tissue viability. We have evaluated a new,

Increased fetal leptin in type I diabetes mellitus pregnancies complicated by chronic hypoxia.

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OBJECTIVE The purpose of this study was to examine whether fetal leptin concentration correlates with severity of chronic or subchronic fetal hypoxia as indicated by increased fetal concentrations of erythropoietin in fetuses of mothers with Type I (insulin dependent) diabetes mellitus. METHODS We

[Endocrine function of the pancreas in experimental diabetes mellitus of rats and its characterization during adaptation to hypoxia].

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The present research was aimed at examination of the endocrinal system of the pancreas in diabetes mellitus, adaptation to hypoxia, and their combination in rats in order to elucidate the relationships between A, B, and D cells under various conditions. The status of Langerhans islet cells was

[Tissue oxygenation and tissue hypoxia in diabetes mellitus].

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The-Polarographic method was applied to the study of free oxygen tension (PO2) in the subcutaneous cellular tissue and the muscle of the arm in 104 patients suffering from diabetes mellitus without any concomitant pathology of the lungs and in 25 healthy persons. At the period of decompensation of

Effects of aspirin plus alpha-tocopherol on brain slices damage after hypoxia-reoxygenation in rats with type 1-like diabetes mellitus.

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Diabetes mellitus is a risk factor for cerebrovascular ischemic disease. Aspirin (acetylsalicylic acid) is the most widely used drug for the secondary prevention of thrombotic phenomena. It has been also recently demonstrated that alpha-tocopherol influenced in vitro the antiplatelet effect of

[Intermittent hypoxia due to sleep apnea syndrome in patients with type 2 diabetes mellitus].

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OBJECTIVE To evaluate the possible association between intermittent hypoxia (IH) and HbA1c in patients with insufficient control type of 2 diabetes mellitus (T2DM). METHODS In this cross-sectional study 183 patients with HbAc1≥7% underwent three-channel overnight monitoring (ApneaLink) and completed

Heat shock protein-70 and hypoxia inducible factor-1α in type 2 diabetes mellitus patients complicated with retinopathy.

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OBJECTIVE To elucidate the role of heat shock protein-70 (HSP70) and hypoxia inducible factor-1α (HIF-1α) in diabetic retinopathy (DR) patients. METHODS A comparative study was done on the serum level of both HSP70 and HIF-1α in 50 patients with type 2 diabetes mellitus (T2DM) without DR, 50

Effect of intermittent hypoxia on the cardiac HIF-1/VEGF pathway in experimental type 1 diabetes mellitus.

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OBJECTIVE High altitude and hypoxic preconditioning have cardioprotective effects by increasing coronary vascularity, reducing post-ischemic injury, and improving cardiac function. Our purpose was to examine if intermittent hypoxia treatment has any restoring effects related to the possible role of

[Pathogenetic therapy of tissue hypoxia, hemorheologic disorders and microangiopathies in patients with diabetes mellitus].

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To reveal oxygen transport and hemorheological changes in derangements of carbohydrate metabolism, a unified scheme for patients' examination was devised. It includes examination of oxygen metabolism, rheological blood properties (viscosity of the whole blood, hematocrit, viscosity of erythrocyte

The impact of hypoxemia on nephropathy in extremely obese patients with type 2 diabetes mellitus.

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OBJECTIVE Diabetes mellitus (DM) is associated with obstructive sleep apnea (OSA) and nephropathy. The hypoxemia associated with OSA may exacerbate renal deterioration in DM nephropathy. We examined the role of hypoxemia in the development of DM nephropathy in severely obese patients. METHODS This

Effect of garlic on rats with chronic intermittent hypoxia combined with diabetes mellitus.

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The present study investigated the effect of garlic (G) on serum, liver, renal and cerebral parameters of rats with chronic intermittent hypoxia (CIH) combined with diabetes mellitus (DM). A total of 32 rats were divided into eight groups, with 4 rats/group. A total of three models were established,

Effect of hypoxia on heart rate variability and baroreflex sensitivity during hypoglycemia in type 1 diabetes mellitus.

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OBJECTIVE Patients with type 1 diabetes mellitus exhibit impairments in autonomic and cardiovascular control which are worsened with acute hypoglycemia--thus increasing the risk of adverse cardiovascular events. Hypoxia, as seen with the common comorbidity of sleep apnea, may lead to further

Diabetes mellitus impairs vasodilation to hypoxia in human coronary arterioles: reduced activity of ATP-sensitive potassium channels.

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ATP-sensitive K+ channels (K(ATP)) contribute to vasomotor regulation in some species. It is not fully understood the extent to which K(ATP) participate in regulating vasomotor tone under physiological and pathophysiological conditions in the human heart. Arterioles dissected from right atrial

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