The single bite technique involved removing the forceps with its specimen after each individual biopsy.

The double-bite technique involved taking an initial biopsy, repositioning the forceps, and taking another biopsy from the same area with the initial specimen still on the forceps.

Hereditary Diffuse Gastric Cancer

During biopsy collection one specimen will be retrieved during a single passage of the biopsy forceps.

Single bite biopsy technique

During biopsy collection two specimens will be retrieved during a single passage of the biopsy forceps.

Double bite biopsy technique

MRC Cancer Unit

Biopsy Technique for Endoscopic Surveillance of Hereditary Diffuse Gastric Cancer

Single-bite Versus Double-bite Technique for Mapping Biopsies During Endoscopic Surveillance of Hereditary Diffuse Gastric Cancer: a Single Center, Randomized Controlled Trial

Evaluating the diagnostic yield of the double-bite technique, by means of identifying SRCC foci, in comparison to the conventional single -bite arm.

Differences between the study arms in terms of time required for biopsy collection

Differences between the study arms in terms of size of the biopsy specimens

Differences between the study arms in terms of patient comfort score, during the procedure. Comfort score is reported after the procedure, according to the modified Gloucester scale.
1: No discomfort - resting comfortably throughout; 2: Minimal. One or two episodes of mild discomfort, well tolerated; 3:Mild. More than 2 episodes of discomfort, adequately tolerated; 4: Moderate. Significant discomfort experienced several times during the procedure; 5: Severe. Extreme discomfort, experienced frequently during the procedure

Differences between the study arms in terms of dose required for sedation

Massimiliano di Pietro, MD

Senior Clinician Scientist. Consultant Gastroenterologist.

University of Cambridge

Intervention arm: administration of
Flowtron Hydroven boot in the Emergency Department
Coban2 Lite after surgery
Flowtron Hydroven boot after surger, before discharge

The leg is elevated on a Braun frame. This is the "old fashioned" conservative treatment to prevent swelling.

Ankle Fractures

The patient in the intervention group will use both compression boot and compression bandage, as described in intervention arm

Flowtron Hydroven and Coban2 Lite

Braun frame

application of flowtron hydroven boot and compression bandage

compression bandage

Unit of Orthopedic Surgery, Nordsjællands Hospital

Compression in Anklefracture Treatment, The CAT-study

The project manager will evaluate the patient twice during the 6 weeks follow-up, in the out-patient clinic. Clinical pictures will be taken at each visit, for two senior doctors to perform a blinded evaluation according to the primary outcome. Infection is defined as Increased pain, swelling, pus secretion, redness, or warmth around the affected area. Need for antibiotics. Not all signs has to be present. The outcome is registred as "number of patients with infection"

Dehisence of the epidermis or the entire dermis. Can be answered with yes/no

Pale, dark or non-vital skin, sorrounding the wound.

Is the osteosynthesis material visible when the wound is examined or probed during the 2nd. and 6th. week examination in the out-patient clinic. Can be answered with no/yes/a little/ a lot

Blisters (pale or dark) from the knee and down. Can be answered with yes/no

Pain, swelling and tenderness in one of the legs, heavy ache in the affected area.
Warm skin in the area of the clot. Redness of the skin. Elevated D-dimer, confirmation of diagnosis by ultrasound. Can be answered with yes/no

Amputation og the ankle. Can be answered with yes/no

Rikke Winge

PhD-student, MD

Hillerod Hospital, Denmark

The Research Unit, Northzealand Hospital

Department of Orthopedic Surgery, Northzealand Hospital

Non-small Cell Lung Cancer

Hiv-positive

Pemetrexed + Carboplatin
On D1 of a 21-day cycle:
Pemetrexed 500 mg/m² IV in 10 minutes followed 30 minutes later by:
Carboplatin AUC 5 in 30 minutes in 100 ml sterile water or 5% glucose or physiological serum. The carboplatin dose will be calculated by the Calvert formula with a target AUC of 5 mg/mL.min as follows:
Carboplatin dose in mg = 5 x (GFR + 25) GFR is estimated according to the MDRD equation for creatinine clearance
• 4 cycles total

Chemotherapy

Centre Hospitalier du Pays d'Aix

Annemasse - CH

Annecy - CH

Avignon - CH

CH de la Côte Basque

CHU Besancon - Pneumologie

Caen - CHU Côte de Nacre

CH Cahors

CH Compiègne - Pneumologie

Créteil - CHI

CHU Grenoble - pneumologie

Le Mans - Centre Hospitalier

Hôpital de la Croix Rousse

Hôpital Louis Pradel

APHM - Hôpital Nord

Montpellier - CHRU

Nevers - CH

Centre Antoine Lacassagne

CHR d'Orléans La Source

APHP - Hopital Tenon - Pneumologie

GH Paris Saint-Joseph

Hôpital Saint Antoine

Paris - Pitié-salpêtrière

Pau - CH

Centre François Magendie - hôpital du Haut-Lévèque

HCL - Lyon Sud (Pneumologie)

Reims - CHU

Rennes - CHU

Saint Brieuc - CHG

NHC - Pneumologie

Suresnes - Hopital Foch

Thonon les bains - CH

Toulon - CHI

CHU Toulouse - Pneumologie

Tourcoing - CH

Tours - CHU

CH Valence

Chemotherapy for Lung Cancer in HIV-positive Patients

Phase II Trial Evaluating the Efficacy and Safety of Carboplatin Plus Pemetrexed in Human Immunodeficiency Virus Positive (HIV+) Patients With Stage III (Not Amenable to Radiation or Inoperable) or Stage IV Nonsquamous Non Small Cell Lung Cancer

diastase/rak

Biopsy Technique for Endoscopic Surveillance of Hereditary Diffuse Gastric Cancer

Compression in Anklefracture Treatment, The CAT-study

Chemotherapy for Lung Cancer in HIV-positive Patients

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