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Metabolism of Diazepam and Ethosuximide in rats with malaria and endotoxin-induced fever.

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We have investigated the effects of malaria infection with rodent parasite Plasmodium berghei and fever induced by Escherischia coli endotoxin on the metabolism of diazepam to temazepam by rat liver microsomes, and on the clearance of ethosuximide in vivo in the rat. Livers from malaria-infected

Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome.

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The serotonin (5-HT) syndrome is the most serious toxic interaction of antidepressants, but no pharmacotherapy has yet been established. In the present study, we created an animal model of the 5-HT syndrome by intraperitoneally injecting rats with clorgyline (2 mg/kg) and 5-hydroxy-L-tryptophan

In vitro modulation of adriamycin and mitoxantrone cytotoxicity by hyperthermia and diazepam, in human chronic myeloid leukemia cells.

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Adriamycin and mitoxantrone are known antitumor agents. The use of these agents is limited by their toxicity to normal body tissue. This paper shows that it is possible to achieve greater log cell-kill by using these drugs in combination with hyperthermia and diazepam. Experiments were carried out

Neuroendocrine effects of diazepam and flesinoxan in the stress-induced hyperthermia test in mice.

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In the stress-induced hyperthermia (SIH) paradigm in mice, both a benzodiazepine receptor agonist, diazepam, and a 5-HT1A receptor agonist, flesinoxan, reduced the stress-induced increase in rectal temperature. The SIH procedure itself enhanced plasma ACTH and corticosterone levels but not plasma

A case of malignant hyperthermia during epidural analgesia.

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Malignant hyperthermia syndrome developed during epidural analgesia in 25-year-old female to be operated on for haemorrhoidal varices. After premedication with diazepam and atropine epidural analgesia was started with lidocaine 300 mg and bupivacaine 50 mg. Signs and symptoms of malignant

Oral Diazepam in Febrile Seizures Following Acellular Pertussis Vaccination.

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Febrile seizure is the most common type of seizures among children, which is a terrible and frightening experience for parents who are concerned about its recurrence. The aim of this study was to evaluate the effect of diazepam on preventing the recurrence of febrile seizure following

Intermittent prophylaxis of recurrent febrile seizures with clobazam versus diazepam.

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Febrile seizures are the most common type of seizure among children that can be prevented by using prophylactic drugs like Clobazam and Diazepam. The present prospective study was conducted in the Department of Pediatrics, Mymensingh Medical College Hospital and Community Based Medical College

Diazepam versus clobazam for intermittent prophylaxis of febrile seizures.

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OBJECTIVE To compare the effectiveness of intermittent clobazam versus diazepam therapy in preventing the recurrence of febrile seizures and assess adverse effects of each drug. METHODS This prospective randomized controlled trial was performed on neurologically normal children aged from 6 months to

Intermittent prophylaxis in febrile convulsions: diazepam or valproic acid?

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In an open, prospective, randomized, and hospital-based study, comprising 219 consecutive children, 169 were given intermittent prophylaxis for one year, receiving either diazepam or valproic acid after their first febrile convulsion. Children admitted on odd dates (n = 89) were given rectal

[Indications for intermittent diazepam prophylaxis in febrile seizures].

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BACKGROUND In a prospective controlled study we evaluated the efficacy of intermittent diazepam prophylaxis in the recurrence rate of febrile seizures (FS). METHODS A total of 139 children aged between 6 and 36 months, who had a first FS, were enrolled in the study and were randomly allocated to two

Calcium uptake into muscle of pigs susceptible to malignant hyperthermia: in vitro and in vivo studies with and without halothane.

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MHS and normal pigs were anaesthetized with nitrous oxide and diazepam. Halothane 1% was then administered for 1 hr. Immediately before and immediately after the halothane inhalation, 10 g of vastus lateralis muscle was excised. SR was isolated from this muscle. Calcium accumulation by the MHS

[A case report of a 63-year-old patient with malignant hyperthermia].

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We have experienced a case of fulminant malignant hyperthermia who was a 63-year-old female weighing 44 kg. There was no particular past history nor family history. She underwent right mastoidectomy because of chronic otitis media. Her preoperative physical status was ASA I. She was premedicated

Interaction of apomorphine and stressors in the production of hyperthermia in the rabbit.

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Apomorphine-induced hyperthermia in the rabbit was shown to be dependent upon the presence of stressors. Two types of stressors were used: 1) a physical stressor, foot shock; and 2) an emotional stressor, conditioned fear. Apomorphine (4 mg/kg i.v.), in the absence of a stressor, produced behavioral

Hyperthermia and hypermetabolism in focal cerebral ischemia.

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The reliable and reproducible creation of an animal model of focal cerebral ischemia is not easily accomplished. Using a transortibal approach, we showed that occlusion of the posterior cerebral artery (PCA), middle cerebral artery (MCA), and the contralateral anterior cerebral artery (ACA) created

Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis.

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Convulsions triggered by fever are the most common type of seizures in childhood, and 20% to 30% of them have recurrence. The prophylactic treatment is still controversial, so we performed a systematic review to find out the effectiveness of continuous phenobarbital and intermittent diazepam

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