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Stranica 1 iz 89 rezultatima
Dopaminergic Dysfunction in Late-Life Depression
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Late Life Depression (LLD) is a prevalent, disabling, and at times lethal condition for which currently available treatments are often ineffective. No prior study has comprehensively examined dopamine-dependent behaviors (i.e., reward processing, cognition, motor function) in LLD, and none has
Ambroxol as a Novel Disease Modifying Treatment for Lewy Body Dementia
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The increasing prevalence of dementia is a serious threat to our medical system and our society. About 500,000 Canadians are affected with dementia, and this number will rise to more than 1 million in the next 20 years. Dementia already costs our economy 15 billion dollars per year. While much of
Dopaminergic restauratIon by intraVEntriculaire Administration
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Parkinson's disease (PD) is the second most frequent neurodegenerative disorder worldwide. The loss of dopamine through denervation in the striatum as a result of progressive neuronal degeneration in the substantia nigra pars compacta (SNpc), is the primary neurotransmitter marker of the disease.
Insulin Resistance in Multiple System Atrophy
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Multiple system atrophy (MSA) patients have a poor prognosis with a median survival ranging between 6 and 10 years. MSA belongs to the synucleinopathies, which are characterized by the abnormal accumulation of alpha-synuclein. We have recently shown brain insulin resistance (i.e. reduced insulin
[18F]F-DOPA Imaging in Patients With Autonomic Failure
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Natural History and Disease Progression Biomarkers of Multiple System Atrophy
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Surrogate biomarkers are objectively measured characteristics of a disease which act as indicators of the underlying pathophysiological processes responsible for disease progression. Reduced grey matter volume in putamen, cerebellum and brainstem as measured with MRI have been consistently reported
Molecular and Functional Imaging in SNCA, Parkin and PINK1
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Intensity of Aerobic Training and Neuroprotection in Parkinson's Disease
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A short description, 5000 characters Intro: In phenotypic animal models of Parkinson's Disease (PD), chronic physical exercise has produced nigrostriatal neuroprotection and symptom improvement, provided training was of high-intensity and prolonged duration (>3 months in rodent models). Conventional
Physical Therapy and Cognitive Decline
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Non-pharmacological intervention may represent adjunctive therapy to medications in order to delay the onset of the cognitive deficits or dementia.
Previous studies observed a positive effect of cognitive training on cognition both in healthy elderly people and patients in the early stage of
Search for Biomarkers of Neurodegenerative Diseases in Idiopathic REM Sleep Behavior Disorder
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REM sleep behavior disorder (RBD) is a parasomnia characterized by dream enactment behaviors and REM sleep without muscle atonia (excessive EMG activity) during REM sleep.Increasing studies revealed that iRBD eventually converts to α-synucleinopathy, such as Parkinson's disease (PD), dementia with
Ultrasound Meal Accommodation Test for Enteral Feeding in the Critically Ill
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Within the context of intensive care units (ICU), enteral nutrition is an essential tool in the management of critical patients, because it preserves the structure and function of the gastrointestinal mucosa, decreases the catabolic response to injury when it is administered early, and could also
Unravelling the Alteration of Brain Structure and Function in Parkinson´s Disease With Ultra-high Field MRI
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BACKGROUND Parkinson's disease (PD) is a multi-system neurodegenerative disease affecting a subset of vulnerable cells in various brain structures, including brain stem nuclei. Selective degeneration of dopamine (DA) producing neurons in the pars compacta of the substantia nigra (SNc) is a key
Non-invasive Ventilation vs Oxygen Therapy After Extubation Failure
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Patients. Medical and surgical patients admitted to intensive care unit with 18 years of age or older in weaning from their first episode of mechanical ventilation for more than 24 hours were included. Patients with structural neurological disorder, acute toxic-metabolic neurological encephalopathy
Precision Medical Diagnosis for Parkinson's Disease ─ The Quantitative Analysis System for PET/MRI Images in Patients
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Parkinson's disease (PD) is a neurodegenerative disease whose pathogenic mechanism is the degeneration of substantia nigra of the midbrain, causing the degeneration of dopaminergic neurons in the putamen and caudate nucleus of the striatum, and the dopamine content in the synapses decreases and
Adrenergic Blockers for Cardiac Changes in Early Parkinson's Disease
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Idiopathic Parkinson's disease (PD) is a progressive neurodegenerative disorder of unknown etiology, characterized by bradykinesia (slowness of movements) associated with tremor at rest and/or muscle rigidity. PD is typically associated with a significant loss of dopaminergic neurons in the
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