endometrial neoplasms/nikotin

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[Metabolic effect of tobacco smoke and "switching" the estrogen effect: mechanism of increased genotoxicity].

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Earlier studies demonstrated dynamic changes in the hormonal and genotoxic effects of estrogens and a decrease in estradiol concentrations and/or aromatase (estrogen synthetase) activity in the uterine tissue in rats exposed to tobacco smoke (TS) and in endometrial and breast tumor tissues of female

Nicotine attenuates global genomic DNA methylation by influencing DNMTs gene expression in human endometrial stromal cells.

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Background

There is increasing evidence indicating an incidence of infertility and also the risk of endometrial cancers among smokers. However, the mechanism underlying nicotine adverse effect on female reproduction remains unclear. Growing evidence has suggested that

Beneficial effects of nicotine and cigarette smoking: the real, the possible and the spurious.

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Cigarette smoking is an established risk factor for cancer and cardiovascular disease, and is the leading cause of avoidable disease in most industrialized countries. Less well-known are possible beneficial effects, which are briefly considered in this survey. Preliminary data suggest that there may

A retrospective study of tamoxifen and endometrial cancer in breast cancer patients.

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OBJECTIVE To assess the relationship between low-dose tamoxifen, usage and endometrial cancer in breast cancer patients. METHODS In this case-control study, the records of the 1017 patients treated at Wilford Hall Medical Center for primary breast cancer between 1978 and 1989 were reviewed. Dose and

Cigarette smoking and endometrial cancer risk: the modifying effect of obesity.

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The objective of this study was to evaluate the association between cigarette smoking and endometrial cancer risk by investigating potential modifying effects of menopausal status, obesity, and exogenous hormones. We pooled data from three case-control studies with the same study design conducted in

[Diagnosis of cervical and endometrial cancer].

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Updated French guidelines for clinical practice have been published by the National Cancer Institute in 2010, concerning the diagnosis and the treatment of cervix and endometrial cancers. The diagnosis of cervix cancer, suspected when a cervix tumour is observed in a patient presenting with vaginal

Cytochrome P450 1A1, cigarette smoking, and risk of endometrial cancer (United States).

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Cytochrome P450 1A1 (CYP1A1) is involved in the metabolism of estradiol and the activation of polycyclic aromatic hydrocarbons found in tobacco products. Polymorphic variation in CYP1A1 activity may modify susceptibility to endometrial cancer through the oxidative metabolism of estradiol and the

Hospital-based study of endometrial cancer survival in Mumbai, India.

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BACKGROUND Endometrial cancer is common in western women, and the rates are very high; however in India, the rates are as low as 4.3 per 100,000 (Delhi). OBJECTIVE To estimate the survival of endometrial cancer patients based on age, education, family history, tobacco habit, number of pregnancies,

Swelling among women who need education about leg lymphedema: a descriptive study of lymphedema in women undergoing surgery for endometrial cancer.

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OBJECTIVE In addition to hysterectomy and bilateral salpingo-oophorectomy, comprehensive surgical staging for endometrial cancer includes pelvic and para-aortic lymphadenectomy. Clarifying and addressing the morbidity from these surgical procedures is imperative. The goal of this study was to assess

Tobacco use and cancer causation: association by tumour type.

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In the second part of our review we describe the association between tobacco use and risk of specific cancer types. There is evidence for an established association of tobacco use with cancer of the lung and larynx, head and neck, bladder, oesophagus, pancreas, stomach and kidney. In contrast,

Endometrial Cancer: An Overview of Pathophysiology, Management, and Care.

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To provide an overview of the etiology, diagnosis, treatment, and survivorship concerns surrounding endometrial cancer.A review of articles dated 2006-2018 from PubMed and NCCN guidelines.Endometrial cancer is the most common

Development and Validation of a Serum Metabolomic Signature for Endometrial Cancer Screening in Postmenopausal Women

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Importance: Endometrial carcinoma (EC) is the most commonly diagnosed gynecologic cancer. Its early detection is advisable because 20% of women have advanced disease at the time of diagnosis. Objective:

Comorbidity of schizophrenia and cancer: clinical recommendations for treatment.
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The paper analyzes some issues on the comorbidity between schizophrenia and cancer. Epidemiological studies have reported contradictory results, but it is certain that patients with schizophrenia are more likely to suffer from risk factors for cancer development, such as increased alcohol abuse,

Cancer incidence in female smokers: a 26-year follow-up.
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A random sample of 26,000 Swedish women who were asked about their smoking habits in the early 1960s have now been followed for 26 years with respect to cancer incidence. Most findings regarding tobacco smoking and cancer from studies of men were confirmed also among the women. Elevated relative

Cigarette Smoking Affects Uterine Receptivity Markers.
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Smoking negatively affects fertility and the rate of other endometrial diseases. To determine the effect of smoking on endometrial physiology, we evaluated 2 endometrial regulatory cytokines and receptivity markers, C-X-C motif chemokine ligand 12 (CXCL12) and fibroblast growth factor 2 (FGF2), both

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