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Biochemical alterations of connective tissue metabolism in the arterial walls of stroke-prone spontaneously hypertensive rats.

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1. The chemical characteristics of the vascular connective tissue components were determined in stroke-prone (SP), stroke-resistant (SR) spontaneously hypertensive (SH) rats and normotensive Wistar-Kyoto (WK) rats. 2. The ratio of hydroxylysine to hydroxylsine plus lysine in the vascular collagen

Chemical analysis of vascular collagen in stroke-prone spontaneously hypertensive rats.

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Chemical characteristics of vascular collagen were studied in stroke-prone spontaneously hypertensive rats (SHRSP) which developed cerebrovascular lesions spontaneously in over 90% of the population. Aminoacid analysis of arterial collagen among SHRSP showed no remarkable difference from

Genotype at the P554L variant of the hexose-6 phosphate dehydrogenase gene is associated with carotid intima-medial thickness.

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OBJECTIVE The combined thickness of the intima and media of the carotid artery (carotid intima-medial thickness, CIMT) is associated with cardiovascular disease and stroke. Previous studies indicate that carotid intima-medial thickness is a significantly heritable phenotype, but the responsible

Early pathophysiological changes in cerebral vessels predisposing to stroke.

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We studied the early pathophysiological response of lenticulostriate arterioles in rats in three models of human conditions associated with stroke: (a) chronic angiotensin II-hypertension; (b) chronic nicotine administration; (c) oxidative endothelial injury. In all three models, quantitative patch

Glucose and NADPH oxidase drive neuronal superoxide formation in stroke.

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OBJECTIVE Hyperglycemia has been recognized for decades to be an exacerbating factor in ischemic stroke, but the mechanism of this effect remains unresolved. Here, we evaluated superoxide production by neuronal nicotinamide adenine dinucleotide phosphate (NADPH) oxidase as a possible link between

Serum metabolites and risk of myocardial infarction and ischemic stroke: a targeted metabolomic approach in two German prospective cohorts.

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Metabolomic approaches in prospective cohorts may offer a unique snapshot into early metabolic perturbations that are associated with a higher risk of cardiovascular diseases (CVD) in healthy people. We investigated the association of 105 serum metabolites, including acylcarnitines, amino acids,

A novel mechanism of non-feminizing estrogens in neuroprotection.

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Estrogens are potent and efficacious neuroprotectants both in vitro and in vivo in a variety of models of neurotoxicity. We determined the structural requirements for neuroprotection in an in vitro assay using a panel of >70 novel estratrienes, synthesized to reduce or eliminate estrogen receptor

Photosynthesis: a short history of some modern experimental approaches.

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This paper presents a personal interpretation of a chapter of plant physiology beginning from the early 1930s to the early 1940s, when plant physiologists tried to find the missing link between the two (dark and light) phases of photosynthesis. As initially inferred by Richard Willstätter and Arthur

A histochemical study of cerebral cortical vessels and ganglionic vessels of the caudatoputamen in aging normotensive rats.

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The goal was to describe the metabolic profile of ganglionic and cortical arteries and arterioles in aging normotensive male rats. Five enzymes indicative of key metabolic pathways in the vessel walls were semiquantitatively evaluated using bright-field histochemical microscopy. Lactate

A comparison of different carbohydrates as substrates for the isolated working heart.

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Ribose has been shown to greatly enhance ATP recovery in situations such as postischemia when total adenine nucleotides have been depleted by catabolism. In addition, metabolic studies have reported that both five carbon sugars and alcohols (ribose and xylitol) can support energy metabolism

Plasma galactocerebrosides in multiple sclerosis.

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Plasma cerebrosides were examined in 12 cases of multiple sclerosis which were compared to normal controls and patients with cerebrovascular accidents. A screening was performed so as to select patients with levels above to normal by means of thin-layer chromatography of the lipid extract. Glucose

Metabolism in human endomyocardial biopsies and cardiac work.

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The activities of the Krebs cycle (KC), glycolytic pathway (GP), and the hexose monophosphate shunt were studied in endomyocardial biopsies obtained from 25 patients and were related to left ventricular stroke work index (LVSWI). Unexpectedly, KC activity was greater in patients with a reduced LVSWI

Forebrain ischemia in diabetic and nondiabetic BB rats studied with 31P magnetic resonance spectroscopy.

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In spontaneously diabetic BB rats, the effect of chronically maintained blood glucose levels on the degree of energy failure and brain pH change during an ischemic insult, and on subsequent recovery after reperfusion, was studied with in vivo 31P magnetic resonance spectroscopy. Short duration

Occlusion of left atrial appendage affects metabolomic profile: focus on glycolysis, tricarboxylic acid and urea metabolism.

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UNASSIGNED Left atrial appendage (LAA) closure (LAAC) by implantation of an occlusion device is an established cardiac intervention to reduce risk of stroke while avoiding intake of oral anticoagulation medication during atrial fibrillation. Cardiac interventions can alter local or systemic gene and

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