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Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid Disorders

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This is an intervention, prospective, monocentric study. Enrolled patients will undergo 3 visits: - Adrenal insufficiency (AI) patients: patients affected by primary or secondary adrenal insufficiency, whether newly diagnosed or on established glucocorticoid therapy, will be evaluated at baseline

Absorption and Bioavailability of Major Monoterpenes in Mastiha Oil; a Kinetic Study in Humans.

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After enrolment, the volunteers will undergo a medical and dietary assessment and their health status will be evaluated through a complete blood count. On the day of the experiment and after overnight fasting, the volunteers will consume g of mastiha oil (1ml) and blood samples will be obtained on

Gut Microbiota and Multiple Sclerosis

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Multiple sclerosis is a pro-inflammatory demyelinating disease of the central nervous system. The etiology of MS is complex and poorly understood. Both genetic and environmental factors play a role and recent evidence suggests that gut microbiota is one of the key environmental factors. Gut

The Role of Dietary Tryptophan on Aryl Hydrocarbon Receptor Activation

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The Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor implicated in a range of key cellular events. In the gut, AHR is crucial for maintaining intestinal barrier immune homeostasis. The physiology of the AHR, however, is not completely understood; its precise gut luminal

Effects of Short-chain Fatty Acids on Inflammatory and Metabolic Parameters in Maintenance Hemodialysis

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End-stage renal disease (ESRD) is associated with multiple comorbidities such as cardiovascular disease, anemia, mineral and bone disorders, malnutrition, body wasting, muscle loss (sarcopenia), neurological problems and infections resulting in a poor survival. Important promoters of these obstacles

Resveratrol in Knee Osteoarthritis

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Osteoarthritis (OA) is the first cause of handicap in individuals over 40 years-old in France. OA physiopathology is driven in part by local joint inflammation responsible for pain and joint destruction. Experimental studies have shown that resveratrol, a molecule antagonist to the aryl hydrocarbon

Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases

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Non-Aromatic-Very rich in Steranes (NAVS) naphthalan is a transparent, earth mineral oil prepared by a complex set of procedures of separations and refining, starting with a special oil that is used as the raw material for brown naphthalane, which has been successfully used in the treatment of

The Study of ELEctronic Cigarette Toxicity in a Human Model in Vivo Model of Inflammation and Vascular Dysfunction

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Background. Since their introduction, electronic cigarette (EC) use has increased substantially. Perhaps most concerning is the increased use amongst adolescents. Many e-cigarette users believe that electronic cigarettes are safer than conventional cigarettes [1]. However, the toxicities of

Fish or Nuts? Dietary Effects on Cardiometabolic Risk Factors and Persistent Organic Pollutants

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Today more than one-fifth of the adult Norwegian population is obese, and the prevalence of abdominal obesity has increased disproportionately in women. Cardiometabolic disorders (metabolic syndrome, type 2 diabetes) follow in the wake of obesity increasing health burdens on the population.

Molecular, Cytological Features and Genetic Susceptibility of COPD Attributable to Different Environmental Exposures 2

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Study rationale: The main risk factors of COPD are tobacco smoking, biomass smoking and occupational factors. Tobacco smoking is well-known risk factor so tobacco induced COPD is completely established. Nevertheless the meaning of occupational factors which are less famous are equally important.

Molecular, Cytological Features and Genetic Susceptibility of COPD Attributable to Different Environmental Exposures

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Evaluation of Antioxidant Activity of Oral Lutein in Preterm and Term Newborn

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In recent years many scientific studies demonstrated that lutein, a nutrient belonging to the family of carotenoids, may constitute a valid and important preventive and protective factor against a large number of chronic diseases affecting millions of people around the world . Studies from

Placental and Cord Blood Markers Associated With Premature Birth and Disorders of Premature Birth in Newborn Infants

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Prematurity, diseases of prematurity and growth-disorders of newborn infants contribute significantly to morbidity and mortality seen in newborn infants [1,2,3]. One out of eight newborn infants in the USA is born premature (gestational age less than 37 completed weeks). In 2004, of the 27,860

HIPWOODS - Health Effects Related to Exposure to Particle Pollution From Woodburning Stoves

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Public health is concerned with the physical, mental and environmental health of communities and populations at risk for disease and injury. Generally, the determination of health effects associated with indoor and outdoor exposures is difficult since documented cause-and-effect relationships are

Children's Exposures/Health Effects/Diesel Exhaust

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We will recruit 450 subjects ranging from 9 to 11 years old (or 3rd to 5th graders). These children who commute to school will perform repeated monthly measures of pulmonary function tests using spirometry, pulmonary inflammation via exhaled breath, and asthma symptoms and clinical encounters, up to

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