l arginine/hypoxia

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Metabolomics and Wound Healing in Diabetes

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The dysfunction of wound healing in diabetes involves multiple healing processes by diminished inflammatory responses and delayed deposition of matrix components, wound remodeling, and closure. Furthermore, hyperglycemia increases the infection susceptibility of wounds. The wounds noted at distal

Beet the Cold: The Effect of Inorganic Nitrate Supplementation in Individuals With Raynaud's Phenomenon

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Raynaud's phenomenon (RP) is characterised by a recurrent transient vasospasm of the fingers or toes in response to a cold or stressful stimulus. Nitric oxide (NO•) is a known vasodilator and NO• donors, such as Glyceryl Trinitrate (GTN), improve blood flow in patients with RP and in cold sensitive

Impact of NOS, COX, and ROS Inhibition on Cerebral Blood Flow Regulation

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Specific Aims: 1A. Determine the independent contributions of NOS and COX to hypoxic and hypercapnic vasodilation in the MCA of young, healthy adults. 1B. Determine the combined contribution of NOS and COX to hypoxic and hypercapnic vasodilation in the MCA of young, healthy adults. 1. C. Determine

Human Adaptation to High Altitude

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Study aim A: Red cell mass and hypoxia: Various forms of altitude training have been used to increase in particular endurance performance of elite athletes. The most commonly used approaches is either to live and train at altitude (Live high - train high; LHTH) or to live at high altitude while

Immunonutrition in Cardiac Surgery

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Objective To study the effect of two preoperative immune enhancing nutritional supplements compared with a control nutritional supplement in 'high risk' risk cardiac surgery patients Introduction: Elderly patients and patients with a poor ventricular function undergoing cardiac operations with

Effect of Nitrite on Exercise Physiology and Metabolism

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During exercise, there is a lag in the rate at which oxygen uptake (VO2) rises to meet energy demand. It is uncertain whether this limitation is due to inadequate O2 delivery to working muscle, limitations to the rate at which mitochondria can generate ATP to meet demand, or by a combination of

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