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lanatoside c/naprstak
Veza se sprema u međuspremnik
5 rezultatima
Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells.
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Prijava Registriraj se
Recent studies have revealed that cardiac glycosides, such as digitalis and digoxin, have anticancer activity and may serve as lead compounds for the development of cancer treatments. The poor prognosis of hepatocellular carcinoma (HCC) patients reflects the development of resistance to current
Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status.
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BACKGROUND
Hepatocellular carcinoma is the second deadliest cancer with limited treatment options. Loss of PTEN causes the P13K/Akt pathway to be hyperactive which contributes to cell survival and resistance to therapeutics in various cancers, including the liver cancer. Hence molecules targeting
An overview of cardenolides in Digitalis - more than a cardiotonic compound.
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Prijava Registriraj se
The genus Digitalis L. containing species, commonly known as the "foxglove", is the main source of cardenolides, which have various pharmacological properties effective against certain pathological conditions including myocardial infarction, arterial hypertension, cardiac dysfunction, angina, and
Isolation of cardenolides from a Brazilian cultivar of Digitalis lanata by rotation locular counter-current chromatography.
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Prijava Registriraj se
Cardenolides from a Brazilian cultivar of Digitalis lanata were isolated by rotation locular countercurrent chromatography (RLCC), employing dichloromethane-methanol-water (5:6:4, v/v) as the solvent system. Highly pure lanatoside C was obtained from the Digitalis lanata hydromethanolic extract,
Cardioactive Steroid Toxicity
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Cardioactive steroids (CAS) are medically important compounds historically used for conditions like edema and "dropsy." There is literature from the 17th century regarding their therapeutic effects. They are available in several plants including oleander, foxglove, lily of the valley, red squill,
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