Overweight

Microbiota

Endotoxemia

Metabolic Syndrome

Non-Alcoholic Fatty Liver Disease

Insulin Resistance

Substitution of refined sugar by an equivalent quantity of maple syrup (5% of daily energy intake) in the participant diet. A dietitian will help study subjects to target added sugar sources in their usual diet and suggest ways to substitute it with maple syrup.

Maple syrup

Substitution of refined sugar by an equivalent quantity of maple-flavored sucrose syrup (5% of daily energy intake) in the participant diet. A dietitian will help study subjects to target added sugar sources in their usual diet and suggest ways to substitute it with the placebo (sucrose syrup).

Placebo

INAF, Université Laval

Effects of Maple Syrup on Gut Microbiota Diversity and Metabolic Syndrome

Impact of Free Sugar Replacement by Maple Syrup on Prevention of Metabolic Disorders Associated With Overweight in Humans : Role of Gut Microbiota

Plasma Lipopolysaccharides (LPS) and Lipopolysaccharide Binding Protein (LBP)

Measure short chain fatty acids in the feces

Evaluation of gastrointestinal symptoms and stool consistency using standardized questionnaires (the gastrointestinal symptom rating scale (GSRS) and Bristol stool chart)

Evaluation of fat accumulation by magnetic resonance imaging (MRI)

Evaluation of plasma glucose, insulin and c-peptide concentration using a 3-hour oral glucose tolerance test

Evaluation of plasma triglycerides (TG), Total cholesterol, LDL, HDL, Apolipoprotein B and free fatty acids end of two dietary treatment

Evaluation of bmi with weight and height measurements

Evaluation of body composition by osteodensitometry

Evaluation of plasma high sensitive C-Reactive Protein (hs-CRP)

Transcriptomic analyses to investigate underlying mechanisms of action

Metabolomic analyses to investigate underlying mechanisms of action

Evaluation of metabolome: camu-camu derived metabolites, short chain fatty acids, branched chain fatty acids, bile acids, phenolic compounds

Evaluation of systolic and diastolic blood pressure

André Marette

Professor

Laval University

Personalized diet added with quinoa and flaxseed

Personalized diet without dietary supplement

Nutritional and Metabolic Diseases

Quinoa

Flaxseed

personalized diet added with quinoa and flaxseed

Quinoa and Flaxseed

Epidemiología y determinantes sociales asociados a la obesidad y la diabetes tipo 2 en México

NORMA Oficial Mexicana NOM-037-SSA2-2012, Para la prevención, tratamiento y control de las dislipidemias.

Diferencias entre la prevalencia de obesidad y exceso de peso estimadas con datos declarados o por medición directa en adultos de la Comunidad Valenciana

Consumer Acceptability of Muffins with Flaxseed (Linum usitatissimum)

Flavonoids and other phenolic compounds in Andean indigenous grains: Quinoa (Chenopodium quinoa), kañiwa (Chenopodium pallidicaule) and kiwicha (Amaranthus caudatus)

Nutraceuticals and Functional Foods in Health Promotion and Disease Risk Reduction

Inhibition of reverse transcriptases by flavonoids

Utilidad de la Prueba de Micronúcleos y Anormalidades Nucleares en Células Exfoliadas de Mucosa Oral en la Evaluación de Daño Genotóxico y Citotóxico

Procedimientos básicos de la prueba de micronúcleos y anormalidades nucleares en células exfoliadas de mucosa oral

Una nueva definición mundial del síndrome metabólico propuesta por la Federación Internacional de Diabetes: fundamento y resultados

Hospital Civil de Guadalajara "Fray Antonio Alcalde"

Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara

Efect of Quinoa and Flaxseed in Cititoxicity and Glicemic Control in Metabolic Syndrome Patients

Evaluation of the Citotoxicity and Clicemic Control of Subject With Metabolic Syndrome Managed With Conventional Nutritional Tratment More Quinoa, Flaxseed or Borh Versus Conventional Nutrition

The number of micronuclei will be evaluated at baseline at 12 weeks and 24 weeks with Schmidt technique by Giemsa/wright and the entered values reflect the number of micronuclei at week 24

The fasting glucose levels will be evaluated at baseline, at 12 weeks and 24 weeks with enzymatic/colorimetric techniques and the entered values reflect the fasting glucose level at 24 weeks

Glycosylated hemoglobin will be evaluated at baseline, at 12 weeks and 24 weeks by high-pressure liquid chromatography (HPLC) and the entered values reflect the glycosylated hemoglobin at 24 weeks

The body weight will be measured at baseline, at 12 weeks and 24 weeks with a bioimpedance balance and the entered values reflect the body weight at 24 weeks

Body Mass Index will be calculated at baseline, 12 weeks and 24 weeks with the Quetelet index formula and the entered values reflect the body mass index at 24 weeks

Waist circumference will be evaluated at baseline and at 24 weeks with a flexible tape

Total cholesterol levels will be evaluated at baseline and 24 weeks by enzymatic/colorimetric techniques and the entered values reflect the total cholesterol level at 24 weeks

Triglycerides levels will be evaluated at baseline and 24 weeks with enzymatic/colorimetric techniques and the entered values reflect the triglycerides level at 24 weeks

c-HDL levels will be evaluated at baseline and 24 weeks with enzymatic/colorimetric techniques and the entered values reflect the c-HDL level at 24 weeks

c-LDL levels will be evaluated at baseline and 24 weeks with enzymatic/colorimetric techniques and the entered values reflect the c-LDL level at 24 weeks

Blood pressure will be measured at baseline and 24 weeks with a digital sphygmomanometer and the entered values reflect the blood pressure at 24 weeks

El uso de los datos es exclusivo de los investigadores involucrados en el estudio sin la devulgacion de los mismos a terceros externos al equipo de trabajo

Ana Lilia Fletes Rayas

PROFESSOR ASSOCIATE TYPE A

University of Guadalajara

Hospital Civil de Guadalajara

An open clinical trial with randomization plus control group

PreDiabetes

Flaxseed High Dose

Flaxseed Low Dose

University of Colorado Colorado Springs

University of Montana

Does Flaxseed Supplementation Improve Glycemic Control in Individuals With Pre-diabetes?

Andrea Hutchins

Associate Professor

University of Colorado, Colorado Springs

Strawberry, raspberry and cloudberry intervention for 8 weeks

Control diet with restricted berry consumption

Impaired Glucose Tolerance

Low-grade Inflammation

Dyslipidemia

100 g of strawberry puree, 100 g of frozen raspberries and 100 g frozen cloudberries were concumed daily for 8 weeks. Bilberry consumption was restricted.

300 g of strawberry, raspberry and cloudberry

Equivalent amount to 400 g of fresh bilberries were consumed as 40 g of dried bilberries and as 200 g of frozen bilberries. Restriction of use of strawberries, raspberries and cloudberries were set.

400 g of bilberry

Control diet, ie. habitual diet with restriction of berry consumption was consumed for eight weeks

Control diet

University of Eastern Finland, Dpet of Public Health and Clinical Nutrition

The Health Effect of Diet Rich in Nordic Berries

The Effect of Diet Rich in Nordic Berries on Gut Microbiota, Glucose and Lipid Metabolism and Metabolism on Fenolic Compounds

Fasting glucose level oral glucose tolerance status at study week 8

total, HDL and LDL cholesterol level at the study week 8

Various inflammation markers were measured at the study week 8

Markers of cholesterol absorption and synthesis were measured

Global gene expression analyses in peripheral mononuclear cells (PBMC)

Marjukka Kolehmainen

Senior scientist

VTT Technical Research Centre, Finland

healthy lifestyle counseling + 30 grams/day supplement of Flaxseed

Metabolic Syndrome X

flaxseed

Health lifestyle counseling accroding to AHA reccommendation

lignan/pretilost

Effects of Maple Syrup on Gut Microbiota Diversity and Metabolic Syndrome

Efect of Quinoa and Flaxseed in Cititoxicity and Glicemic Control in Metabolic Syndrome Patients

Does Flaxseed Supplementation Improve Glycemic Control in Individuals With Pre-diabetes?

The Health Effect of Diet Rich in Nordic Berries

Flaxseed Intervention on Metabolic Syndrome

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