Ibuprofen 800mg IV piggyback and Saline IVP q 6 hours x 4 during uterine fibroid embolization

Acetaminophen 1 gram IV piggyback and Saline IVP q6 hours x 4 during uterine fibroid embolization

Ibuprofen 800 mg/ Acetaminophen 1 gram IV piggyback and Saline IVP 6 hours x 4 during uterine fibroid embolization

Saline/Saline IV piggyback and IVP Ketorolac 30 mg q6 hours x 4 during uterine fibroid embolization

Ibuprofen 800mg IV piggyback and Saline IVP q 6 hours x 4.
IV Ibuprofen

Intravenous Ibuprofen

Acetaminophen 1 gram IV piggyback and Saline IVP q6 hours x 4
IV Acetaminophen

Intravenous Acetaminophen

Ibuprofen 800 mg/ Acetaminophen 1 gram IV piggyback and Saline IVP 6 hours x 4
IV Ibuprofen
IV Acetaminophen

IV Ibuprofen/IV Acetaminophen

Saline/Saline IV piggyback and IVP Ketorolac 30 mg q6 hours x 4
IV Placebo

Intravenous Placebo/Intravenous Placebo

Total

Sex: Female, Male

Region of Enrollment

Primary efficacy objective is to compare the change in maximum level of pain experienced by patient over 24 hours between IV acetaminophen and IV ibuprofen (alone and in combination), and the current standard of care medication regimen. This comparison will be measured using a visual analog scale (VAS) from 0 to 10, 0 signifying no pain and 10 signifying the worst possible pain. The scores reported are the mean of all patients' VAS scores in each respective category.

Evaluation of Maximum Pain Intensity Change Over 24 Hours With the Addition of IV Acetaminophen and IV Ibuprofen

Primary efficacy objective is to compare the change in mean pain intensity score over 24 hours between IV acetaminophen and IV ibuprofen (alone and in combination), and the current standard of care medication regimen. This comparison will be measured using a visual analog scale (VAS) from 0 to 10, 0 signifying no pain and 10 signifying the worst possible pain. The scores reported are the mean of all patients' VAS scores in each respective category.

Evaluation of Mean Pain Intensity Over 24 Hours With the Addition of IV Acetaminophen and IV Ibuprofen

Assessment of mean nausea by mean of VAS scores over a 24-hour period. VAS score is measured using a scale of 0 to 10, 0 signifying no nausea and 10 signifying the worst possible nausea. The scores reported are the mean of all patients' VAS scores in each respective category.

Mean Nausea Intensity

Mean opioid consumption in morphine equivalents over 24 hours

Opioid Consumption

Mean dose of anti-emetic medication in milligrams given over 24 hours

Anti-Emetic Consumption

Assessment of maximum level of nausea experienced by patient, by mean of VAS scores over a 24-hour period. VAS score is measured using a scale of 0 to 10, 0 signifying no nausea and 10 signifying the worst possible nausea. The scores reported are the mean of all patients' VAS scores in each respective category.

Maximum Nausea Intensity

Overall Study

Director of Clinical Research

Symptomatic Uterine Fibroids and Adenomyosis

IV Ibuprofen

IV Acetaminophen

Intravenous placebo/Intravenous placebo

Ronald Reagan UCLA Medical Center

Santa Monica/UCLA Medical Center and Orthopaedic Hospital

Effectiveness of IV Acetaminophen and IV Ibuprofen in Reducing Post Procedural Pain in the UFE Procedure

A Prospective, Double Blind, Randomized, Placebo Controlled Study to Compare the Effectiveness of Intravenous Acetaminophen and Intravenous Ibuprofen in Reducing Post Procedural Pain in the Uterine Fibroid Embolization Procedure

menorrhagia/skopolamin

Effectiveness of IV Acetaminophen and IV Ibuprofen in Reducing Post Procedural Pain in the UFE Procedure

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