mitomycin c/karijes

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Induction chemotherapy with cisplatin, etoposide, and mitomycin-C (PEM) regimen in advanced cases with cancer of pharynx and oral cavity.

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With the aim of improving survival rate in advanced head and neck cancer, we scheduled 26 patients to receive PEM regimen. This regimen consisted of cisplatin (CDDP)(P), etoposide (VP-16)(E), and mitomycin-C (MMC)(M) (CDDP 60 mg/ m2/2 hr infusion on day 1; VP-16 40 mg/m2/1 hr infusion on days 1-3;

[Arterial infusion of microencapsulated mitomycin C for the treatment of locally recurrent carcinoma of the pelvic cavity].

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Ethylcellulose microcapsules of mitomycin C (MMC) were prepared. The potential therapeutic effects of intra-arterial infusion of the microencapsulated anti-cancer drugs were considered to be a function of microembolization and prolonged the drug action, that is, chemoembolization. A total of 19

Safe application of mitomycin C within the nasal cavity.

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OBJECTIVE To describe a novel technique of delivering mitomycin C safely via endoscopic sinus surgery. METHODS Mitomycin C was applied in the median frontal drainage pathway of a 44-year-old woman suffering from recalcitrant chronic frontal sinusitis. The mitomycin C was soaked onto a neurosurgical

[Preoperative chemotherapy targeting lymphatic apparatus in the peritoneal cavity of gastric cancer patients with serosal invasion using mitomycin C bound to activated carbon particles].

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Surgical Outcomes Post Neoadjuvant Chemotherapy in Stage IV cancers of Oral Cavity.

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OBJECTIVE To know the effect of neoadjuvant chemotherapy on surgical outcomes (R1 resections, post-operative complications, recurrence and follow up) in Stage IV borderline operable cancers of oral cavity. METHODS Patients in group A (n=45) were those who were referred for neoadjuvant chemotherapy

Histologic changes induced by intraperitoneal chemotherapy with 5-fluorouracil and mitomycin C in patients with peritoneal carcinomatosis from cystadenocarcinoma of the colon or appendix.

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Intraperitoneal chemotherapy with mitomycin C and 5-fluorouracil has been used to rescue patients from peritoneal carcinomatosis after perforated cystadenocarcinoma of the large bowel or appendix. A staging celiotomy was used to asses the results of therapy. In nine patients tumor was recovered from

Mechanism of the development of resistance to mitomycin C in Hirosaki sarcoma.

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In the peritoneal cavity of the rat, Hirosaki sarcoma, as ascites tumor of the rat, acquired a resistance to the essentially effective dose of 100 microgram/kg of mitomycin C by means of the daily treatment with the ineffective dose of 10 or 1 microgram/kg of mitomycin C. It is considered that most

Properties of water-insoluble mitomycin C-albumin conjugate as a sustained release drug delivery system in mice inoculated with Sarcoma 180.

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In order to improve the deposition of mitomycin C (MMC) in the administered site, water-insoluble mitomycin C-albumin conjugate (MMC-G-BSA) was prepared. MMC was covalently attached to the glutarylated bovine serum albumin (G-BSA) in the presence of 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide

Topical Mitomycin-C can help as an adjunct to alkaline nasal wash and rifampicin in primary atrophic rhinitis.

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Primary atrophic rhinitis (PAR) is a well-known old disease characterized by a roomy nose and extensive crustations. This study was designed to investigate the effect of topical Mitomycin-C as an adjunct to medical treatment with respect to objective and subjective improvement in

Topical mitomycin C as an adjunct to surgical debulking and medical treatment in rhinoscleroma.

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BACKGROUND Rhinoscleroma is a chronic granuloma that is endemic in Egypt and is caused by gram-negative bacilli (Klebsiella rhinoscleromatis). The nasal mucosa is affected in almost all cases, which causes nasal obstruction, anosmia, and epistaxis. The disease usually passes through an atrophic

Topical mitomycin C as an adjunct to surgical debulking and medical treatment in rhinoscleroma.

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[Continuous hyperthermic peritoneal perfusion with cisplatin and mitomycin C for peritoneal dissemination in gastric cancer].

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Thirty-four patients with advanced gastric cancers had received continuous hyperthermic peritoneal perfusion (CHPP) for prevention or treatment of peritoneal dissemination (PD). These patients received intra-abdominal perfusion 30-40 minutes by about 10-liter saline heated to 50-52 degrees C

[Mitomycin C after endoscopic endonasal dacryocystorhinostomy].

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Mitomycin-C (MMC) is the most frequently used agent for prevention of excessive scarring at the osteotomy site after endoscopic endonasal dacryocystorhinostomy (EEDCR), which, however, being applied during the final stage of the surgery, shows questionable effectiveness. OBJECTIVE to evaluate the

Synthesis and biological evaluation of a cross-linked hyaluronan-mitomycin C hydrogel.

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A cross-linked hyaluronan (HA) hydrogel that contained a covalently bound derivative of the anti-proliferative drug mitomycin C (MMC) was synthesized and evaluated in vitro and in vivo. The HA-MMC hydrogel was prepared by coupling MMC-aziridinyl-N-acrylate with thiol-modified HA followed by

Induction chemotherapy is associated with an increase in the incidence of locoregional recurrence in patients with carcinoma of the oral cavity: results from a single institution.

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BACKGROUND This study was conducted to determine long term survival rates and the pattern of failure in patients with carcinoma of the oral cavity treated with induction chemotherapy or preoperative radiotherapy followed by surgery. METHODS A retrospective analysis was performed of 141 eligible

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