neoplasm metastasis/phosphatase

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Phosphatase associated with metastasis

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BACKGROUND OF THE INVENTION 1. Field of the Invention The invention relates to the field of cancer diagnostics and therapeutics. In particular it relates to a gene which appears to be significantly associated with the progression of cancer to more advanced stages, including metastasis. 2. Background

Method for activating T cell protein tyrosine phosphatase for therapeutic applications

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FIELD OF THE INVENTION This invention relates to a method for activation of T cell protein tyrosine phosphatase (TCPTP) and a method for inhibiting tyrosine kinase signalling in an individual. Further, the invention concerns a method for preventing or treating a disease or disorder in an individual,

Modulation of pleiotrophin signaling by receptor-type protein tyrosine phosphatase beta/zeta

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BACKGROUND OF THE INVENTION Pleiotrophin (PTN) is a platelet-derived growth factor-inducible heparin-binding growth and differentiation factor that signals diverse phenotypes in normal and deregulated cellular growth and differentiation. See Milner, et al., (1989) Biochem. Biophys. Res. Commun. 165,

Method for treating a disorder associated with Eya dysregulation by modulating Eya phosphatase activity

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BACKGROUND The molecular pathways involved in proliferative disorders and oncogenesis often represent aberrations of processes that normally occur during embryogenesis. One such pathway implicated in proliferative disorders such as cancer is the evolutionally conserved gene network termed the

Methods for treating and preventing prostate cancer bone metastases

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TECHNICAL FIELD The present disclosure relates generally to methods of treating a subject having a prostate cancer bone metastasis. The present disclosure also relates to methods of prophylactically treating a subject at risk of developing a prostate cancer bone metastasis. In particular, the

Crystal of a phosphatase of regenerating liver 1 (PRL-1) polypeptide and method of crystallization thereof

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TECHNICAL FIELD The present invention relates to a crystal structure of PRL-1 protein and a method of crystallization thereof, more precisely, a method of crystallization of PRL-1 protein including the steps of mass-expressing human originated PRL-1 protein in E-coli transformant and purifying those

Shp-2 inhibitors and pharmaceutical compositions comprising them

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The present invention relates to small molecule protein tyrosine phosphatase inhibitors, especially Shp-2 inhibitors, of formulae (I) and/or (II), and to pharmaceutical compositions comprising them. The invention is also directed to the use of said compounds for the treatment of phosphatase-mediated

SSH-2 (slingshot-2) inhibitors and methods for making and using them

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TECHNICAL FIELD This invention generally relates to biochemistry, medicine and drug discovery. In particular, in alternative embodiments, the invention provides compositions that inhibit the polypeptide SSH-2, or Slingshot-2 (SlingSHot-2), a phosphatase enzyme that regulates actin filaments, and

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