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Antiproliferative Activity and Characterization of Metabolites of Aspergillus nidulans: An Endophytic Fungus from Nyctanthes arbor-tristis Linn. against Three Human Cancer Cell Lines.

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BACKGROUND Endophytic fungi are receiving attention as sources of structurally novel bioactive secondary metabolites towards drug discovery from natural products. This study reports the isolation and characterization of secondary metabolites from an endophytic fungus Aspergillus nidulans, associated

Depletion of tumor necrosis factor-alpha in mice by Nyctanthes arbor-tristis.

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The effect of the water soluble fraction of the ethanol extract of Nyctanthes arbor-tristis (NAT) on tumor necrosis factor-alpha (TNF-alpha) level in plasma of arthritic and soluble protein A (SpA)-treated Balb/c mice has been studied. Oral administration of this fraction in arthritic mice showed a

Betulinic Acid, the first lupane-type triterpenoid isolated via bioactivity-guided fractionation, and identified by spectroscopic analysis from leaves of Nyctanthes arbor-tristis: its potential biological activities in vitro assays.

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Betulinic acid was first time isolated via bioactivity-guided fractionation from ethyl acetate extract of Nyctanthes arbor-tristis leaves. Its structure was established by FTIR, 1H and 13C- nuclear magnetic resonance and high-resolution mass spectrometry. It had shown excellent inhibition of

Altersolanol A: a selective cytotoxic anthraquinone from a Phomopsis sp.

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The cytotoxic compound Altersolanol A, an anthraquinone derivative was isolated from PM0409092 a fungus of Nyctanthes arbor-tristis (family Oleaceae). It was identified as a Phomopsis sp. by DNA amplification and sequencing of the ITS region. The chemical structure of Altersolanol A was elucidated

Poly herbal formulation with anti-elastase and anti-oxidant properties for skin anti-aging.

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BACKGROUND Skin forms an important part of human innate immune system. Wrinkles, thinning and roughening of skin are some of the symptoms that affect the skin as it ages. Reactive oxygen species induced oxidative stress plays a major role in skin aging by modulating the elastase enzyme level in the

Nyctanthes arbor-tristis positively affects immunopathology of malaria-infected mice prolonging its survival.

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In order to search for new products that display antimalarial and immunomodulatory mechanisms that complement direct antiparasitic activity, a set of in vitro and in vivo experiments were designed to evaluate the effect of Nyctanthes arbor-tristis in Plasmodium berghei infected mice. Three extracts

Biochemical characterization of radical scavenging polyphenols from Nyctanthes arbortristis.

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BACKGROUND Antioxidants are quenchers of free radical that are responsible for inducing oxidative stress generated via reactive oxygen species-induced degenerative diseases such as cancer, diabetes, and cardiovascular diseases etc. Plant and plant products are recognized as safe and potential health

Antiinflammatory Activity of Hot Water Infusion of Nyctanthes arbo-tristis Flowers.

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In Sri Lankan ethnomedicate it is claimed the flowers of Nyctanthes arbo-tristis is effective in the treatment of inflammatory conditions but this has not been scientifically validated. This experiment was carried to investigate the antinflammatory potential of hot water infusion of Nyctanthes

Comparative studies of different organs of Nyctanthes arbortristis in modulation of cytokines in murine model of arthritis.

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OBJECTIVE To study the modulation effect of pro- and anti-inflammatory cytokines following long term use of water soluble ethanol extracts from different organs of Nyctanthes arbortristis (NAT) in mouse model of arthritis. METHODS Arthritis was induced in mice by two injections of Freund's complete

In vitro antioxidant, antiproliferative, and phytochemical study in different extracts of Nyctanthes arbortristis flowers.

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Nyctanthes arbortristis L. (Oleaceae) is widely used in the Indian system of traditional medicine and is reported to have various biological activities. The present study was intended to evaluate the antioxidant and antiproliferative activities of flower extracts of Nyctanthes arbortristis. The

Silica induced early fibrogenic reaction in lung of mice ameliorated by Nyctanthes arbortristis extract.

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OBJECTIVE To investigate the pharmacological effect of Nyctanthes arbortristis (NAT) leaf extract in the prevention of lung injury induced by silica particles. METHODS Lung injury was induced in Swiss mice through inhalation exposure to silica particles (< 5 mu) using a Flow Past Nose Only

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