periodontitis/proline

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Free amino-acid composition of wax-stimulated whole saliva in human subjects with healthy periodontium, severe chronic periodontitis and post-juvenile periodontitis.

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The free amino-acid composition of wax-stimulated whole saliva of 3 subjects with different periodontal status was determined. The amino acids were analysed by gas chromatographic separation on a packed column and determined as their N-heptafluorobutyrylisobutyl esters. In 2 patients with

Activity of dipeptidyl peptidase II and dipeptidyl peptidase IV in human gingiva with chronic marginal periodontitis.

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The activity of DPP II was higher in gingiva from patients with periodontitis, but the activity of DPP IV, post-proline cleaving enzyme and collagenase-like peptidase was not significantly higher than that of the control group. As DPP II activity is known to be altered in immunological diseases,

Protease activity in gingival crevicular fluid from discrete periodontal sites in humans with periodontitis or gingivitis.

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Sensitive fluorogenic assays were used to compare the protease activities of fluid collected from eight such sites in each of 21 adult patients with gingivitis and 22 with periodontitis. The degradation of N-carbobenzoxy-gly-gly-arginine-AMC, L-arginine-AMC, glyproline-AMC, L-leucine-AMC,

Peroxisome proliferator-activated receptor gamma polymorphism and periodontitis in pregnant Japanese women.

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BACKGROUND Recent studies suggest an association between maternal periodontitis and preterm birth, although the association remains controversial. It was suggested that mechanisms such as a genetic predisposition for a hyperinflammatory response cause periodontitis and preterm births. Peroxisome

Characterization of bone resorbing activity in gingival crevicular fluid from patients with periodontitis.

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BACKGROUND In attempts to elucidate factors stimulating bone resorption in patients with different inflammatory diseases in the vicinity of the skeleton, e.g., peridontal disease and rheumatoid arthritis, we are investigating the presence of bone-resorbing activity in a variety of inflammatory

Gingival crevicular fluid from patients with periodontitis contains bone resorbing activity.

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Inflammatory processes occurring in the vicinity of bone tissue often result in stimulation of osteoclast activity and loss of skeletal mass. The aim of the current study was to determine if inflammatory exudates collected from gingival pockets in patients with periodontitis contain factors capable

Using NMR in saliva to identify possible biomarkers of glioblastoma and chronic periodontitis.

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Nowadays there is increasing interest in identifying-and using-metabolites that can be employed as biomarkers for diagnosing, treating and monitoring diseases. Saliva and NMR have been widely used for this purpose as they are fast and inexpensive methods. This case-control study aimed to find

Proteomic analysis of whole saliva in chronic periodontitis.

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Periodontitis is a chronic inflammatory disease resulting from a dysbiosis of the dental biofilm and a dysregulated host response in susceptible individuals. It is characterized by periodontal attachment destruction, bone resorption and eventual tooth loss. Salivary biomarkers have been sought to

Analysis of salivary phenotypes of generalized aggressive and chronic periodontitis through nuclear magnetic resonance-based metabolomics.

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BACKGROUND Recent findings about the differential gene expression signature of periodontal lesions have raised the hypothesis of distinctive biological phenotypes expressed by generalized chronic periodontitis (GCP) and generalized aggressive periodontitis (GAgP) patients. Therefore, this

Effect of non-surgical periodontal therapy on salivary metabolic fingerprint of generalized chronic periodontitis using nuclear magnetic resonance spectroscopy.

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OBJECTIVE Metabolomic analysis of saliva proved its accuracy in discriminating patients with generalized chronic periodontitis (GCP) from healthy subjects by identifying specific molecular signatures of the disease. There is lack of investigations concerning the effect of periodontal treatment on

Japanese subgingival microbiota in health vs disease and their roles in predicted functions associated with periodontitis.

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The present study aimed to identify and compare the microbial signatures between periodontally healthy and periodontitis subjects using 454 sequences of 16S rRNA genes. Subgingival plaque samples were collected from ten periodontally healthy subjects and ten matched chronic periodontitis patients.

Free amino-acid content of wax-stimulated human whole saliva as related to periodontal disease.

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This content was analysed in patients with chronic periodontitis and in control subjects. In periodontal disease, it was characterized by higher mean concentrations of glycine, proline, tyrosine and delta-aminovaleric acid than in controls (p less than 0.001). However, the range of values varied

Free amino acid levels in oral fluids of normal subjects and patients with periodontal disease.

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The content of free amino acids in submandibular, parotid and whole saliva and in gingival fluid was measured by automatic analyser in patients with progressive periodontitis and in controls. The concentration of individual amino acids showed considerable variation in all the fluids. Two amino

The biological role of the female sex hormone estrogen in the periodontium--studies on human periodontal ligament cells.

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BACKGROUND Several studies have addressed the association between changes in levels of the female sex hormone, estrogen, and changes in the parameters of periodontitis, but the mechanism behind estrogenic effects in the periodontium is poorly understood. There are two subtypes of estrogen receptors

Functional importance of estrogen receptors in the periodontium.

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The main functions of estrogen are associated with reproduction. However, estrogen has been shown to be of functional importance also in non-classic target organs. Previous studies, especially epidemiologic and clinical ones, have addressed estrogen's influence on periodontitis, suggesting that

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