Once the patient is randomized to either of the 2 groups using computer-generated randomization blocks, the hospital pharmacist would provide the appropriate medications. The treating ophthalmologist, microbiologist and patients will be masked to the drug by using similar vials. The experimental group (Group 1) will receive 1% voriconazole eye drop (Aurolab, Madurai, India) + 5% Natamycin ophthalmic suspension eye drop hourly (USP 5% Natamet, M.J. Pharmaceuticals, Mumbai, India).
The subjects will be hospitalized for at least 4 days with medications given by the ward nurse.
Patients will be followed up every week after being discharged until complete resolution is noted.

Once the patient is randomized to either of the 2 groups using computer-generated randomization blocks, the hospital pharmacist would provide the appropriate medications. The treating ophthalmologist, microbiologist and patients will be masked to the drug by using similar vials. The placebo group (Group 2) will receive Vehicle eye drops + 5% Natamycin ophthalmic suspension every hour (USP 5% Natamet, M.J. Pharmaceuticals, Mumbai, India).
The subjects will be hospitalized for at least 4 days with medications given by the ward nurse.
Patients will be followed up every week after being discharged until complete resolution is noted.

Infection, Fungal

Group 1 Natamycin 5% Suspension + voriconazole 1% eye drops; Group 2 Natamycin 5% Suspension + Vehicle eye drops

GMRV Campus LV Prasad Eye Insitute

Combination Treatment of 5% Natamycin and 1% Voriconazole in Fungal Keratitis

Combination Treatment of 5% Natamycin and 1% Voriconazole in Fungal Keratitis: a Prospective Randomized Double Masked Clinical Trial

Primary End point:
Complete success: Complete resolution of the infiltrate with formation of a scar on medical treatment alone Partial success: Complete resolution of the infiltrate on medical treatment and use of cyanoacrylate glue and bandage contact lens Failure: Worsening of the ulcer necessitating therapeutic penetrating keratoplasty or evisceration

improvement in best corrected visual acuity

Charitha

L.V. Prasad Eye Institute

Individual usual carbohydrate estimation methods (weighing, experience, carbohydrate exchange tables etc.).

Diabetes Mellitus, Type 1

Carbohydrates

The GoCARB system is a smartphone application designed to support type 1 diabetic patients with carbohydrate counting by providing automatic, accurate and near real-time CHO estimation for non-packed foods.

Smartphone App

Click here for more information about GoCARB

Division of Endocrinology, Diabetes and Clinical Nutrition, Bern University Hospital

Carbohydrate Estimation Supported by the GoCARB System

Carbohydrate Estimation Supported by the GoCARB System in Individuals With Type 1 Diabetes

Calculated from daily bolus, basal and correction insulin

Postprandial glucose levels within, below and above target

Measured in kcal and documented by photographs

Composite measured by questionnaire: Participants will be invited to complete three questionnaires: i) a carbohydrate counting specific questionnaire including questions concerning educational level and former training of carbohydrate counting, and ii) a questionnaire related to GoCARB's features.

potato/atrophy

Combination Treatment of 5% Natamycin and 1% Voriconazole in Fungal Keratitis

Carbohydrate Estimation Supported by the GoCARB System

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