Vitamin C Deficiency

Smoking

Surgery

Surgery--Complications

Wound

Wound Complication

Wound Infection

Wound Dehiscence

Wound of Skin

Mandible Fracture

Mandible Open Fracture

Mandible Closed Fracture

Mandibular Fractures

Ascorbic Acid Deficiency

Oxidative Stress

Inflammation

Just after induction of anesthesia in the OR, subjects will be administered a single intravenous (IV) dose of Vitamin C at 66mg/kg/hr for 2 hours during surgery. Post-operatively (beginning the morning after surgery) Vitamin C Treatment Group subjects will receive a 4 week prescription of oral, liquid Vitamin C, 500mg by mouth two times a day. These dosages are known to be safe and effective.89-91

Vitamin C

Subjects will receive IV placebo (normal saline) identically packaged. Post-operatively Placebo Control Treatment Group participants will receive a 4-week prescription of the aqueous solution base used for the treatment group without the active component (Vitamin C).

Placebo

Hennepin Healthcare Research Institute

The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients

The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients: A Double Blind, Placebo-controlled Randomized Clinical Trial

Biomarker of soft tissue repair. Measured in picogram/milliliter (pg/ml) in blood serum.

Biomarker of soft tissue repair. Measured in picogram/milliliter (pg/ml) in blood

Biomarker of soft tissue repair. Measured in nanogram/milliliter (ng/ml) in blood

Biomarker of soft tissue repair. Measured in micro Molar uM in blood

Biomarker of soft tissue repair. Measured in nanomol/microliter (nmol/ul) in blood

Biomarker of bone repair. Measured in enzyme unit/liter (U/L) in blood

Biomarker of bone repair. Measured in picogram/milliliter (pg/ml) in blood

Biomarker of bone repair. Measured in nanogram/milliliter (ng/ml) in blood

Vitamin C levels. Measured in nanomols (nmmol) in blood serum

Biomarker of tobacco exposure. Measured in nanograms/milliliter (mg/ml) in blood serum.

Wounds are scored from photographs using the InCISE wound score developed by the investigator.

Regions Hospital

University of Minnesota

Patients will be randomised to treatment with Deferoxamine (n=87). Deferoxamine (0.66mg/ml) will be applied locally as a gel (3 times a week) for a period of maximum three months or until intact skin.

Patients will be randomised to treatment with placebo (n=87). Placebo will be applied locally as a gel (3 times a week) for a period of maximum three months or until intact skin.

Diabetic Foot Ulcer

Deferoxamine (0.66mg/ml) will be applied locally as a gel (3 times a week) for a period of maximum three months or until intact skin.

Deferoxamine

Placebo will be applied locally as a gel (3 times a week) for a period of maximum three months or until intact skin.

Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers

number of patients who have intact skin healing

the number of patients who have ulcer healing improvement of > 50%

Sergiu Catrina

Associated professor

Karolinska University Hospital

prospective, randomised, double-blind and placebo-controlled study with parallel groups, multiple centre trial.

The drugs (active or placebo) will be supplied by the supervision of Medigelium AB and will have the same appearance.

Patients will be randomized (by block randomization) to Desferal (DFO) treatment.

Patients will be randomized (by block randomization) to isotonic saline treatment.

Diabetes Mellitus, Type 1

It is a blinded randomized cross-over study that investigates the efficacy of DFO (50mg/kg) given i.v before intermittent hypoxia (IH) to improve the cardiorespiratory and angiogenetic response in patients with diabetes.

desferal

It is a blinded randomized cross-over study that investigates the efficacy of isotonic saline given i.v before intermittent hypoxia (IH) to improve the cardiorespiratory and angiogenetic response in patients with diabetes.

Isotonic saline

Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes

The absolute amount of endothelial precursor cells in 10 ml of blood

Senior consultant / associated professor

This is a randomised, double-blind, placebo-controlled, cross-over, single center study of patients with diabetes mellitus type 1 without chronic complications.

proline/hypoxia

The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients

Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers

Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes

Hypoxia Inducible factor1-Alpha Genetic Polymorphism of Obstructive Sleep Apnea

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