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6 rezultatima
Substituted prolines / piperidines as orexin receptor antagonists
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Prijava Registriraj se
BACKGROUND
Orexins are a family of homologous peptides including species orexin A, or OR-A, and orexin B, or OR-B. Orexin A is a 33 amino acid peptide and orexin B is a 28 amino acid peptide (Sakurai T. et al., Cell (1998), 92, 573-585). Orexins are produced in neurons of the lateral hypothalamus
Substituted prolines/piperidines as orexin receptor antagonists
Samo registrirani korisnici mogu prevoditi članke
Prijava Registriraj se
BACKGROUND
Orexins are a family of homologous peptides including species orexin A, or OR-A, and orexin B, or OR-B. Orexin A is a 33 amino acid peptide and orexin B is a 28 amino acid peptide (Sakurai T. et al., Cell (1998), 92, 573-585). Orexins are produced in neurons of the lateral hypothalamus
Substituted prolines/piperidines as orexin receptor antagonists
Samo registrirani korisnici mogu prevoditi članke
Prijava Registriraj se
BACKGROUND
Orexins are a family of homologous peptides including species orexin A, or OR-A, and orexin B, or OR-B. Orexin A is a 33 amino acid peptide and orexin B is a 28 amino acid peptide (Sakurai T. et al., Cell (1998), 92, 573-585). Orexins are produced in neurons of the lateral hypothalamus
Protein hydrolysate enriched in peptides inhibiting DPP-IV and their use
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The present invention relates to a protein hydrolysate enriched in certain peptides, such isolated peptides, and the use of such protein hydrolysate or isolated peptide for the manufacture of a medicament, food supplement, beverage or food product for prophylaxis and/or treatment of a DPP-IV
Soft protease inhibitors, and pro-soft forms thereof
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BACKGROUND OF THE INVENTION
Proteases are enzymes that cleave proteins at specific peptide bonds. Proteases can be classified into four generic classes: serine, thiol or cysteinyl, acid or aspartyl, and metalloproteases (Cuypers et al., J. Biol. Chem. 1982, 257, 7086. Proteases are essential to a
Constrained cyano compounds
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FIELD OF THE INVENTION
The present invention relates to constrained cyano compounds and to their use as selective inhibitors of post-proline/alanine cleaving amino-dipeptidases. The invention further relates to methods of employing such inhibitors, alone or with another therapeutic agent, to treat
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