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Stranica 1 iz 103 rezultatima
Effects of the chiral isomers of erythro- and threo-9-(2-hydroxy-3-nonyl)adenine on purine metabolism in sarcoma 180 cells.
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The effects of the chiral isomers of erythro- and threo-9-(2-hydroxy-3-nonyl)adenines (EHNA and THNA) on purine metabolism in Sarcoma 180 cells have been determined. At concentrations of 10-80 microM [10- to 1000-fold greater than their Ki values with adenosine deaminase (ADA)], all isomers
Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate.
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We examined the antitumor effects of two antifolate inhibitors of thymidylate synthesis, N-(5-[N-(3, 4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino ]-2-theno yl-L-glutamic acid (D1694; Tomudex) and 1843U89 as well as a folate-based inhibitor of purine synthesis, 5,
Alternating purine-pyrimidine tract activates transcription from the Rouse sarcoma virus LTR lacking promoter and enhancer elements.
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The transcriptional control region of the Rouse sarcoma virus long terminal repeats (LTR) was shown to contain enhancer and promoter elements located within 200 base pairs upstream from the transcription initiation site [Cullen et al. (1985) Mol. Cell. Biol. 5, 438-447]. Deletion of these elements
Sensitivity of Nakahara-Fukuoka sarcoma to antitumor agents, especially to purine analogs.
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Purine nucleoside phosphorylase from human erythrocytes. 3. Inhibition by the inosine analog formycin B of the isolated enzyme and of nucleoside metabolism in intact erythrocytes and sarcoma 180 cells.
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Tissue culture screening of purines and purine nucleosides for selective damage to mouse sarcoma cells.
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Inhibition of purine biosynthesis de novo in sarcoma 180 ascites cells by mercapto and seleno purine analogs.
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Purine transport in cultured-normal and mouse sarcoma virus-transformed rat kidney cells.
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Feedback inhibition of purine biosynthesis in adenocarcinoma 755 and sarcoma 180 cells in culture.
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Biochemical mechanisms for the synergism between 6-thioguanine and 6-(methylmercapto)purine ribonucleoside in sarcoma 180 cells.
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The utilization of nucleotides by the mammal. VI. Purine nucleotides totally labeled with C14 in mice bearing sarcoma 180.
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Chemotherapy of sarcoma 180 by combinations of DL-glyceraldehyde with 6-thioguanine or with azaserine and 6-chloro-purine.
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Conversion of 6-thioguanine to the nucleoside level by purine nucleoside phosphorylase of sarcoma 180 and sarcoma 180/TG ascites cells.
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[Studies on the cell division inhibitory effect of some purine and pyrimidine derivatives on Paracentrotus lividus and on sarcoma 180 of mice].
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Utilization of preformed purines by sarcoma 180 or hepatoma 134 cells treated with 6-chloropurine or a combination of 6-chloropurine and azaserine.
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