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pyrrolidine/duhan

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ČlanciKlinička ispitivanjaPatenti
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Biosynthesis of nicotine in Nicotiana glutinosa from carbon-14 dioxide. Labeling pattern in the pyrrolidine ring.

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The biosynthesis of nicotine in Nicotiana glutinosa from carbon-14 dioxide. Labeling pattern in the pyrrolidine rings.

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Synthesis of pyrrolidine ring of nicotine from several C14-labeled metabolites by Nicotiana rustica.

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Enantioselective demethylation of nicotine as a mechanism for variable nornicotine composition in tobacco leaf.

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Nicotine and its N-demethylation product nornicotine are two important alkaloids in Nicotiana tabacum L. (tobacco). Both nicotine and nornicotine have two stereoisomers that differ from each other at 2'-C position on the pyrrolidine ring. (S)-Nicotine is the predominant form in the tobacco leaf,

Why does anatabine, but not nicotine, accumulate in jasmonate-elicited cultured tobacco BY-2 cells?

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Suspension-cultured cells of Nicotiana tabacum cv. Bright Yellow-2 (BY-2) grow rapidly in a highly homogenous population and still exhibit the general behavior of plant cells, and thus are often used as model systems in several areas of plant molecular and cellular biology, including secondary
Nicotine biosynthesis in tobacco (Nicotiana tabacum L.) is highly regulated by jasmonic acid (JA). Two nuclear loci, A and B (renamed NIC1 and NIC2) have been identified that mediate JA-inducible nicotine formation and total alkaloid accumulation. NIC2 was recently shown to be a cluster of seven

Nicotine demethylation in Nicotiana cell suspension cultures: N'-formylnornicotine is not involved.

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Nicotine or nornicotine enriched with stable isotopes in either the N'-methyl group or the pyrrolidine-N were fed to Nicotiana plumbaginifolia suspension cell cultures that do not form endogenous nicotine. The metabolism of these compounds was investigated by analysing the incorporation of isotope

Biogenesis of nicotine.

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Radioactive nicotine was synthesized by Nicotiana rustica L. which was fed sodium acetate-1-C(14), sodium acetate-2-C(14), sodium pyruvate-1-C(14), or sodium pyruvate-3-C(14). Acetate-2-C(14) and pyruvate-3-C(14) were converted to nicotine with the least dilution of radioisotope, whereas

Genomic Insights into the Evolution of the Nicotine Biosynthesis Pathway in Tobacco.

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In tobacco (Nicotiana tabacum), nicotine is the predominant alkaloid. It is produced in the roots and accumulated mainly in the leaves. Jasmonates play a central signaling role in damage-induced nicotine formation. The genome sequence of tobacco provides us an almost complete inventory of structural

A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida.

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Nicotine, the main alkaloid produced by Nicotiana tabacum and other Solanaceae, is very toxic and may be a leading toxicant causing preventable disease and death, with the rise in global tobacco consumption. Several different microbial pathways of nicotine metabolism have been reported: Arthrobacter
In leaf and root tissues of Nicotiana tabacum L. (common tobacco), nicotine is by far the predominant pyridine alkaloid, with anatabine representing only a minor component of the total alkaloid fraction. The pyrrolidine ring of nicotine is derived from the diamine putrescine, which can be

A PIP-family protein is required for biosynthesis of tobacco alkaloids.

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Plants in the Nicotiana genus produce nicotine and related pyridine alkaloids as a part of their chemical defense against insect herbivores. These alkaloids are formed by condensation of a derivative of nicotinic acid, but the enzyme(s) involved in the final condensation step remains elusive. In
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