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reductase/upala

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Stranica 1 iz 41 rezultatima
TECHNICAL FIELD The present invention relates to the combination of certain known therapeutic compounds for therapeutic purposes. The substances used in the combinations according to the invention are known active agents from the phosphodiesterase 4 (PDE4) inhibitor class and active agents from the
BACKGROUND OF THE INVENTION The present invention is directed to a combination method for treating ache using selective 5.alpha.-reductase 1 inhibitors, 5.alpha.-reductase 2 inhibitors, combinations thereof, or dual inhibitors, including but not limited to:

Sepiapterin reductase inhibitors

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BACKGROUND Tetrahydrobiopterin (BH4) is an enzyme cofactor for various aromatic amino acid hydroxylases, including phenylalanine, tyrosine and tryptophan hydroxylases, as well as being an important cofactor for other enzymes such as the nitric oxide synthases (inducible NOS (iNOS), endothelial NOS

Methods involving aldose reductase inhibitors

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BACKGROUND OF THE INVENTION I. Field of the Invention Embodiments of this invention are related generally to physiology and medicine. More specifically, this invention is related to aldose reductase inhibitors (ARIs) and their use in treating and ameliorating inflammation. II. Background Aldose

Methods involving aldose reductase inhibitors

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BACKGROUND OF THE INVENTION I. Field of the Invention Embodiments of this invention are related generally to physiology and medicine. More specifically, this invention is related to aldose reductase inhibitors (ARIs) and their use in treating and ameliorating inflammation. II. Background Aldose

Methods involving aldose reductase inhibitors

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BACKGROUND OF THE INVENTION I. Field of the Invention Embodiments of this invention are related generally to physiology and medicine. More specifically, this invention is related to aldose reductase inhibitors (ARIs) and their use in treating and ameliorating inflammation. II. Background Aldose

Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase

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BACKGROUND The pro-inflammatory cytokines, such as tumor necrosis factor-.alpha. (TNF-.alpha.) and interleukin-1.beta. (IL-1.beta.), contribute to the pathogenesis of various allergic, inflammatory and autoimmune diseases. Consequently, multiple therapeutic approaches have been aimed at reducing the

Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase

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BACKGROUND The pro-inflammatory cytokines, such as tumor necrosis factor-.alpha. (TNF-.alpha.) and interleukin-1.beta. (IL-1.beta.), contribute to the pathogenesis of various allergic, inflammatory and autoimmune diseases. Consequently, multiple therapeutic approaches have been aimed at reducing the

Sepiapterin reductase inhibitors for the treatment of pain

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BACKGROUND OF THE INVENTION In general, the present invention relates to small molecule heterocyclic inhibitors of sepiapterin reductase (SPR), and to the medical use of these compounds. Tetrahydrobiopterin (BH4), which has the following structure, ##STR00001## is an essential cofactor of

Sepiapterin reductase inhibitors for the treatment of pain

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BACKGROUND OF THE INVENTION In general, the present invention relates to small molecule heterocyclic inhibitors of sepiapterin reductase (SPR), and to the medical use of these compounds. Tetrahydrobiopterin (BH4), which has the following structure, ##STR00001## is an essential cofactor of

Materials and methods for inhibiting mamalian S-nitrosoglutathione reductase

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TECHNICAL FIELD Various aspects and embodiments relate generally to materials and methods for inhibiting the enzyme S-nitrosoglutathione reductase (GSNOR) and for diagnosing, studying and treating various conditions and diseases related to the activity of this enzyme. BACKGROUND S-nitrosylation of

Dual action inhibitors against histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme a reductase

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BACKGROUND OF RELATED ART 1. Technical Field The present disclosure relates to the treatment of cancer. More particularly, the disclosed invention relates to the use of novel bi-functional inhibitors against histone deacetylases (HDACs) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase

Pharmaceutical composition and method for inhibiting inflammation

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This application claims priority to Taiwan Patent Application No. 099137186 filed on Oct. 29, 2010. FIELD The present invention relates to a pharmaceutical composition for inhibiting inflammation, especially to a pharmaceutical composition useful for arthritis. BACKGROUND Arthritis is a common

Metabolically inert anti-inflammatory and anti-tumor antifolates

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FIELD OF INVENTION This invention relates to folic acid antagonists that are metabolically inert exhibiting a high level of anti-inflammatory and anti-tumor activity. Metabolically inert classical antifolates are new and therefore they exhibit unexpected biological properties such as those recited
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to amine-borane compounds, including novel heterocyclic amine-boranes, and to a method of inhibiting enzyme (e.g., DNA topoisomerase) activity and/or combatting inflammation, hypolipidemia and/or neoplasia using
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