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sambucus nigra/rak

Veza se sprema u međuspremnik
ČlanciKlinička ispitivanjaPatenti
Stranica 1 iz 148 rezultatima
Anoikis is a form of anchorage-dependent apoptosis, and cancer cells adopt anokis-resistance molecular machinery to conduct metastasis. Here, we report that N-acetylglucosaminyltransferase V gene expression confers anoikis resistance during cancer progression. Overexpression of

Construction and validation of a Sambucus nigra biosensor for cancer-associated STn antigen.

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A label-free electrochemical impedance spectroscopy biosensor for selective detection and discrimination of the cancer-associated sialyl-Tn (STn) antigen was developed by using Sambucus nigra agglutinin type I (SNA-I) as the recognition element. The SNA-I biosensor was constructed by immobilizing
It has previously been reported that about 90% of human colon carcinomas express increased levels of the sialyltransferase which adds sialic acid in alpha 2,6 linkage to galactose residues on N-linked chains of glycoproteins. To ascertain whether colon cancer tissues actually express increased
OBJECTIVE To determine whether the naturally occurring Thomsen-Friedenreich (TF) antigen-specific antibodies differ in avidity between cancer patients and controls to find a novel biomarker for stomach cancer. METHODS Serum samples were taken from patients with cancer and controls. The level of
Colon cancer tissues display an increased activity of beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I) and an increased reactivity with the lectin from Sambucus nigra (SNA), specific for alpha2,6-sialyl-linkages. Experimental and clinical studies indicate a contribution of these alterations to
Increased sialylation of cell surface glycoconjugates has been demonstrated in malignant tumors and shown to be correlated with the invasive and metastatic growth of colon carcinoma cells. The authors have applied the Maackia amurensis lectin, which interacts with alpha 2,3-linked sialic acid, and
Mucin-specific lectin from Sambucus sieboldiana (SSA-M) reacts in Western blotting and ELISA with mucins from porcine stomach, bovine and ovine submaxillary glands, the human milk fat globule membrane, in vitro human ovarian, breast and colonic tumor cell lines, and mucins produced in vivo in the

Sialylation and fucosylation of cancer-associated prostate specific antigen.

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OBJECTIVE To examine sialylation and fucosylation of prostate cancer-associated prostate-specific antigen (PCa PSA) from localized prostate cancer and from metastatic prostate cancer, as relevant indicators of tumour stage-dependent microheterogeneity of its oligosaccharide chain. METHODS Sera and
OBJECTIVE One of the typical modifications on the surface of cancer cells is sialylation of terminal carbohydrates. The expression of several types of sialylation of glycoconjugates was investigated in colorectal cancer. METHODS The cancer tissue specimens obtained from 65 colorectal cancer patients
Differences in cell surface carbohydrates and in laminin and fibronectin synthesis between 2 Ehrlich ascites tumor (EAT) cell lines, the adherent and non-adherent EAT cells, have been studied. The adherent EAT (a-EAT) cells grow in monolayer in vitro in the presence of fetal bovine serum. The
BACKGROUND Alteration of the expression of glycoconjugates is frequently observed in tumors. However, studies on the changes of cellular glycosylation in the early premalignant stage of prostate carcinogenesis are scarce. METHODS The present study characterized and compared the glycoconjugates

Pancreatic cancer serum detection using a lectin/glyco-antibody array method.

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Pancreatic cancer is a formidable disease and early detection biomarkers are needed to make inroads into improving the outcomes in these patients. In this work, lectin antibody microarrays were utilized to detect unique glycosylation patterns of proteins from serum. Antibodies to four potential
In a previous work we found that human colorectal cancer tissues express increased levels of an alpha 2,6 sialyltransferase (alpha 2,6 ST) acting on N-acetyllactosaminic sequences (E.C. 2.4.99.1). In this study we have taken advantage of the known specificity of elderberry bark lectin (Sambucus

Glycoproteomic identification of potential glycoprotein biomarkers in ovarian cancer proximal fluids.

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BACKGROUND Ovarian cancer is the leading cause of death among all gynecological disorders. Aberrant glycosylation, or more specifically, increased sialylation of proteins has been observed in ovarian cancer. Several sialyltransferase genes have been shown to be up-regulated at both the mRNA and

[Expression of glycoconjugates in laryngeal cancer].

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Using the six lectins PNA, SNA, WGA, UEA-1 Amaranthin, and MAA, a cytochemical study was performed to observe the expression of glycoconjugates in squamous cell carcinomas of the larynx in 14 patients and in 3 normal laryngeal epithelia. SNA (Sambucus nigra agglutinin) failed to stain the cytoplasm
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