sclerosis/protease

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Variability of the Unique Fiber Potentials of a Spastic Muscle Treated With Botulinum Toxin

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Stroke is a frequent, serious and disabling condition. Spasticity interferes with the classic motor pattern and reflects reflex motor activities normally inhibited by the central nervous system. This term most frequently refers to a disorder that causes a speed increase dependent on the tonic

Endobronchial Valves Positioning Effects On Diaphragm Function In Patients With Lung Hyperinflation

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Data obtained from clinical and bimolecular studies have showed that chronic obstructive pulmonary disease (COPD) patients might present higher rates of diaphragm function impairment when compared to age and sex matched healthy controls. The potential mechanisms of injury have been found in regional

Clinical Trial to Evaluate the Efficacy of a Dyslipidemic Therapy in Mexican Population

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General objectives: Evaluate the therapeutic efficacy in Mexican adults with dyslipidemia through the oral route use of L-carnitine + atorvastatin in comparison with the use of Atorvastatin, after six months of treatment. Evaluate the safety of the medicines under study. Hypothesis: The combined use

Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery

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3 Background The use of cardiopulmonary bypass (CPB) during cardiac surgery elicits generalized non-specific systemic inflammatory response syndrome (SIRS) and subsequent activation of the cytokine, complement, and coagulation-fibrinolytic cascades (1). In approximately 11% of the patients SIRS may

Tamoxifen Treatment in Patients With Motor Neuron Disease

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The investigators will assess the ALSFR-s in ALS patients at start, 1, 3, 6 and 12 months and correlate the score to the neurological outcome of the patients with and without tamoxifen treatment at dose of 40mg daily for one year. The study will be able to prove the investigators hypothesis:

Doxycycline In Lymphangioleiomyomatosis (LAM)

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Summary We will perform a 2 year double blind, placebo controlled trial of doxycycline in 40 patients with LAM. The main endpoints will be change in FEV1, other measures of efficacy, safety and dose required to suppress MMP activity. After clinical evaluation, lung function, shuttle walk, QoL

Investigation of Neuroserpin as an Autism Candidate Gene

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It is proposed to perform a pilot study to ask whether genetic variation at SERPINI1 is contributing to idiopathic autism. To maximize the chance of finding such variants, the perseveration and language delay endophenotypes (simpler intermediate traits) will be used to select twenty autistic

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