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Misoprostol in Office Hysteroscopy and Endometrial Biopsy

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Office hysteroscopy (OH) and endometrial biopsy (EMB) is increasingly performed for evaluation of various gynecologic conditions. It has replaced traditional dilatation and curettage for evaluation of intrauterine pathology. It is more acceptable to most women as it is quick, safe and cost effective

Progressive Muscle Relaxation According to Jacobson in Treatment of the Patients With Temporomandibular Joint Disorders

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Introduction In the 30s of the previous century, Edmund Jacobson developed the method of progressive muscle relaxation, which is based on the premise that mental relaxation should naturally result from physical relaxation. The primary objective of Jacobson's relaxation is to increase patient`s

THOR - Tübingen Choroideremia Gene Therapy Trial

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Study name: THOR - Tübingen Choroideremia gene therapy trial open label Phase 2 clinical trial using an adeno-associated viral vector (AAV2) encoding Rab-escort protein 1 (REP1) Phase: Phase II Indication: Adult males with a clinical phenotype of choroideremia and a confirmed molecular diagnosis of

Effect of Adjunctive Misoprostol Treatment on Blood Loss at Vaginal Delivery

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Background Some maternal blood loss normally occurs at the time of vaginal delivery. The best estimates indicate that a loss of approximately 500 mL is average, with a range of about 250-700 mL.[1,2] Some of this bleeding arises from birth canal lacerations or surgical incisions (i.e., episiotomy),

Pilot Study to Assess the Safety and Pharmacokinetics of 70-150μm Drug Eluting Beads Loaded With Irinotecan (DEBIRI).

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1. Recruitment: Suitable potential subjects will be identified, namely those who have failed first or second line chemotherapy agents. 2. Liver biopsy Right before the 1st transarterial chemoembolisation procedure, the liver metastases will be biopsied under ultrasound or CT guidance by the IR with

Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome

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The two most important causes of iron overload disease in humans are the iron-loading disorder hereditary hemochromatosis (HC), and transfusional siderosis in patients with chronic hematological diseases like myelodysplastic syndrome (MDS), thalassemia, and leukemia. Hemochromatosis. In HC the

Aspirin Attenuates Inflammation in Human Cerebral Aneurysms

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If you are eligible to enroll in the study, you will be contacted by the principal investigator in person and he will describe the study in a private setting (neurosurgery clinic room or hospital patient room). You will be given ample opportunity to decide to participate or not. You will be randomly

Progression of HIV-Disease Under Low Dose Corticosteroids

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1. INTRODUCTION 1. 1 BACKGROUND For treatment in advanced HIV infection, combination therapy with antiretroviral drugs (ARVs) is the best option under current international standards. The benefit of ARVs is best, if they are used relatively late in the course of the disease, commonly after a

Enteric Coating as a Factor in Aspirin Resistance

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In a recent study we have shown clear evidence for pharmacokinetic aspirin resistance in healthy volunteers due to poor bioavailability of enteric-coated aspirin. However, it is necessary to confirm that pharmacokinetic resistance is an important factor in aspirin resistance in a patient population

a Phase II Study in Primary Central Nervous System Lymphoma

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5 PATIENT SELECTION 5.1 Eligibility Criteria Patients must fulfill all the following criteria to be eligible for admission for the study: 1. Histologically proven central nervous system lymphoma of brain parenchyma with or without leptomeningeal involvement. 2. No evidence of systemic lymphoma. 3.

Comparison of Two Regimens of Misoprostol for Second Trimester Medical Termination of Pregnancy

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Objectives: Misoprostol, a prostaglandin analogue, is principally used to prevent peptic ulcer disease induced by nonsteroidal anti-inflammatory agents .It has been shown to induce second trimester abortion .However , the optimal regimen has not been determined .Studies have used doses ranging 200-

Insulin and Biogenic Amines in Cardiovascular Disease

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BACKGROUND: The Normative Aging Study (NAS) is a multidisciplinary longitudinal study of aging established by the Veterans Adminstration in 1963. Six thousand male volunteers from the Greater Boston area were screened for acceptance into the study according to laboratory, clinical, radiologic and

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