Disclosed are compositions including at least one 5.beta. steroid and an amorphous cyclodextrin. Also disclosed are methods for treating a condition such as obesity, diabetes syndrome, diabetes-associated hypercorticoidism, combinations thereof, and anemic disorders by administering to a mammal in need of such treatment a composition including an obesity-, diabetes-, or anemia antagonistic amount of at least one 5.beta. steroid and an amorphous cyclodextrin. Furthermore, disclosed are methods for treating a subject for a condition that responds to treatment with DHEA by administering to the subject at least one 5.beta. steroid and DHEA in an amount that minimizes the contribution of the DHEA to the production of testosterone and estradiol while maximizing an amount of .alpha.ET and .beta.ET circulating in the subject's blood from an initial dose administered to the subject.

Supergen, Inc.

Formulation for administration of steroid compounds

Novel methods for prevention, reduction or elimination of the incidence of male androgen deficiency symptoms or diseases including male hypogonadism-associated symptoms and diseases associated with low serum testosterone and/or low DHEA or low total androgens in susceptible warm-blooded animals including humans involving administration of an amount of a sex steroid precursor, particularly dehydroepiandrosterone (DHEA) and a selective estrogen receptor modulator (SERM) (particularly acolbifene), an antiestrogen or a prodrug of the two. The symptoms or diseases are loss of libido, erectile dysfunction, tiredness, loss of energy, depression, bone loss, muscle loss, muscle weakness, fat accumulation, memory loss, cognition loss, Alzheimer's disease, dementia, loss of body hair, fertility problems, insomnia, gynecomastia, anemia, hot flushes, sweats, decreased sense of well-being, obesity, osteoporosis, hypercholesterolemia, hyperlipidemia, atherosclerosis, hypertension, insulin resistance, cardiovascular disease and type 2 diabetes. Pharmaceutical compositions for delivery of active ingredient(s) and kit(s) useful to the invention are also disclosed.

Labrie; Fernand

Gauthier; Sylvain

ENDORECHERCHE, INC.

Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM

Endorecherche, Inc.

A dietary system for the treatment of obesity, for the lowering of saturated fats in the blood and, in a modified form, for stimulation of the sympathetic nervous system and general basal metabolism. The system includes a diet that restricts the patient to the intake of certain foods in certain amounts and combines this intake with specific supplements. The supplements include prescribed amounts of vitamins, minerals, and oils. The oils are selected from that group that are high in essential fatty acids such as olive oil and canola oil. The prescribed foods comprise low fat, low carbohydrate, moderate protein foods. By providing the patient with a diet high in essential fatty acids, the glucagon-driven pathway of the patient is stimulated and less fat is stored by the body. In addition, more body fat is catalyzed for the production of energy for use by the body. In its modified form, the diet includes a daily regimen of various hormones including DHEA, progesterone, testosterone, and desiccated thyroid.

testosterone/pretilost

Formulation for administration of steroid compounds

Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM

Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM

Dietary system high in oil intake

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