patients undergoing thyroidectomy for nodular thyroid disease

Postsurgical Hypothyroidism

Hypothyroidism

Patients enrolled in the study will undergo a clinically-indicated thyroidectomy performed as standard of care.

thyroidectomy

Patients will initiate levothyroxine treatment after surgery consistent with standard of care. The drug dosage will be titrated to TSH goal that matches the pre-surgery TSH (+/- 1 mIU/L)

levothyroxine in thyroidectomy patients

University of Colorado Anschutz Medical Campus

Is Levothyroxine Alone Adequate Thyroid Hormone Replacement?

Is Levothyroxine Alone Adequate Thyroid Hormone Replacement for All Patients?

Change in working memory as assessed by pre- vs post-surgery N-back test scores will be measured and compared between those with the deiodinase type 2 CC polymorphism versus those in the deiodinase type 2 TC and TT polymorphism group

Changes in cognitive function assessed by SART testing pre- and post-surgery will be compared between those with the deiodinase type 2 CC polymorphism versus those in the deiodinase type 2 TC and TT polymorphism group

Changes in well-being will be assessed with the SF-36, Billewicz, and HADS tests pre- and post-surgery will be compared between those with the deiodinase type 2 CC polymorphism versus those in the deiodinase type 2 TC and TT polymorphism group

Pre- vs post-surgery N-back test scores will be measured and correlated with pre- and post-surgery serum thyronamine levels

Cognitive function assessed by SART testing pre- and post-surgery will be determined and correlated with pre- and post-surgery serum thyronamine levels

Well-being will be assessed with the SF-36, Billewicz, and HADS tests pre- and post-surgery and will be correlated with serum thyronamine levels pre- and post-surgery

changes in serum thyronamine levels from pre-surgery to end of study (post-surgery) will be assessed

changes in serum sex hormone binding globulin levels from pre-surgery to end of study (post-surgery) will be assessed

changes in serum LDL levels from pre-surgery to end of study (post-surgery) will be assessed

University of Colorado, Denver

Charite University, Berlin, Germany

Patients with preoperatively diagnosed highly differentiated papillary thyroid cancer

Thyroid tumours with preoperative cytology indicating follicular neoplasia, or on cytology suspected but not proven malignancy

Thyroid Neoplasms

Thyroid Cancer

99m Tc- nanocolloid albumin, 10-15 MBq (volume 0.1-0.3 ml) is injected under ultrasound guidance in the thyroid tumour. Imaging (lymphoscintigraphy)with anterior and oblique projections is performed at 60 and 120 min after the injection. SN are mapped intraoperatively by a dedicated SN navigator and excised for final histology.

Histological investigation of the SN

Department of Surgery and Department of Imaging, Skåne University Hospital

Sentinel Lymphnode in Patients With Papillary Thyroid Carcinoma and in Patients With Suspected Thyroid Neoplasia

Sentinel Node Investigation in Patients With Highly Differentiated Papillary Thyroid Carcinoma and in Patients With Thyroid Neoplasia of Unclear Malignant Potential

The histological investigation of the sentinel lymph node(s) (recorded as metastasis or no metastasis), will be compared to the definitive histological investigation of the non SN central lymphnodes (metastasis or no metastasis), cleared by surgery. Sensitivity and specificity of the histological SN investigation to predict the histological outcome of the non SN central lymphnodes (metastasis or no metastasis), will be calculated.

99mTc-nanocolloid albumin will be injected under guidence by ultrasonography. The sensitivity to detect a SN on preoperative imaging (detected SN on imaging/total number of investigations) and during surgery by a collimated probe for SN mapping(SN detected/total number of operations), will be calculated.

Region Skane

patients with positive slope in the levels of free serum calcium levels between 6th and 12th postoperative hour

patients with negative or no slope in the levels of free serum calcium levels between 6th and 12th postoperative hour.

Hypocalcemia After Total Thyroidectomy

G.Hatzikosta General Hospital

The Study of a Safe and Cost-effective Method to Identify Patients at Low Risk of Significant Hypocalcemia After Total Thyroidectomy.

The Study of a Safe and Cost-effective Method to Identify Patients at Low Risk for the Development of Significant Hypocalcemia After Total Thyroidectomy.

thyroid neoplasms/albumin

Is Levothyroxine Alone Adequate Thyroid Hormone Replacement?

Sentinel Lymphnode in Patients With Papillary Thyroid Carcinoma and in Patients With Suspected Thyroid Neoplasia

The Study of a Safe and Cost-effective Method to Identify Patients at Low Risk of Significant Hypocalcemia After Total Thyroidectomy.

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