Typhoid vaccination in single 0.5mL injections into the non-dominant deltoid muscle in the arm

A single 0.5mL injection of 0.9% sodium chloride saline solution into the non-dominant deltoid muscle in the arm

Typhoid Vaccine on Sleep

Typhoid Vaccine injection given 7 days apart

Typhoid Vaccine

Placebo

Investigating the Effects of Typhoid Vaccine on Sleep in Healthy Volunteers

Blood sample taken 2 hours post injection

University of Oxford

Patients receive inactive typhoid vaccine IM at visit 1 followed by placebo IM 30 days later at visit 2.

Patients receive placebo IM at visit 1 followed by inactive typhoid vaccine IM 30 days later at visit 2.

Cognitive Side Effects of Cancer Therapy

Depression

Recurrent Breast Carcinoma

Stage IA Breast Cancer

Stage IB Breast Cancer

Stage IIA Breast Cancer

Stage IIB Breast Cancer

Stage IIIA Breast Cancer

typhoid vaccine

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Wexner Medical Center

Typhoid Vaccine in Testing Response to Immune Stress in Patients With Stage I-IIIA Breast Cancer

The IMPACT Study: Inflammatory Responses, Mood and Physical Fitness After Cancer Treatment

Blood will be drawn for IL-6 in serum samples measured using an electrochemiluminescence method with Meso Scale Discovery kits at the fasting baseline and then every 90 minutes post-inoculation for 7.5 hours.

Self-reported intensity of pain on 0-9 scale (0 = no pain; 9 = pain as bad as you can imagine) at baseline prior to vaccine or placebo administration, and then every 90 minutes post-inoculation for the next 7.5 hours

Self-reported intensity of fatigue on 0-9 scales (0 = no fatigue; 9 = fatigue as bad as you can imagine) at baseline prior to vaccine or placebo administration, and then every 90 minutes post-inoculation for the next 7.5 hours

Janice Kiecolt-Glaser

Principal Investigator

Ohio State University Comprehensive Cancer Center

SEASONAL INFLUENZA VACCINE (0.5ML) DELIVERED I.M.

SEASONAL INFLUENZA VACCINE (0.5ML) DELIVERED I.M.
INFLUENZA VACCINE: THE PURPOSE OF THE STUDY IS TO EVALUATE THE EFFICACY OF THE SEASONAL INFLUENZA VACCINE IN PEOPLE WITH MAJOR DEPRESSIVE DISORDER

VACCINE MDD

SALINE (0.5ML) DELIVERED I.M.
NaCl-saline placebo: placebo

PLACEBO MDD

VACCINE HC

PLACEBO HC

Total

Sex: Female, Male

Region of Enrollment

Outcome data were not collected.
This was a failed study as all participants, including those who were putatively vaccine-naive had antibodies to influenza at baseline and therefore the original hypothesis could not be tested. The study was terminated.

THE TITER OF INFLUENZA ANTIBODIES

THE INFLUENZA VIRUS-INDUCED PROLIFERATION OF CD4+ MEMORY T-CELLS

IL-6 AND TNF PRODUCTION BY STIMULATED AND UNSTIMULATED MONOCYTE CELLS

DIFFERENCES IN RESTING STATE CEREBRAL BLOOD FLOW BETWEEN MDD AND HC GROUPS

DIAGNOSTIC GROUP DIFFERENCES IN THE BOLD RESPONSE (Using fMRI) TO MONETARY REWARDS IN THE VENTRAL STRIATUM

Overall Study

Jonathan Savitz

MAJOR DEPRESSIVE DISORDER

THE PURPOSE OF THE STUDY IS TO EVALUATE THE EFFICACY OF THE SEASONAL INFLUENZA VACCINE IN PEOPLE WITH MAJOR DEPRESSIVE DISORDER

typhoid fever/fatigue

Investigating the Effects of Typhoid Vaccine on Sleep in Healthy Volunteers

Typhoid Vaccine in Testing Response to Immune Stress in Patients With Stage I-IIIA Breast Cancer

Influenza Challenge in Mood Disorders

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