Yerba Mate Extract - Capsules: daily dose of 2.250 g, distributed in 3 doses of 750 mg, for 28 days.

Starch - Capsules: 3 times daily for 28 days.

Cardiovascular Disease

Diabetes

Yerba Mate Extract

Take 3 capsules, 3 times daily for 28 days.

Placebo

Euclides Lara Cardozo Júnior

Yerba Mate (Ilex Paraguariensis A.St.-Hil.): Assessment of Cardiovascular Health

Application of Yerba Mate (Ilex Paraguariensis A.St.-Hil.) Products on the Promotion of Health: Assessment of Cardiovascular Health

Cholesterol - Enzymatic colorimetric method; HDL cholesterol - lipoproteins VLDL (very low density lipoprotein) and LDL (Low Density Lipoprotein) and chylomicrons are precipitated with a mixture of phosphotungstic acid and magnesium chloride. After centrifugation, the bound cholesterol to high density lipoproteins (HDL) in the supernatant determined by colorimetric enzymatic method; Triglycerides - Enzymatic colorimetric method; Fasting glucose - enzymatic colorimetric method.
All results are expressed in mg / dL.

C-reactive protein (CRP) - Kit using turbidimetric methods for the quantitative

Endothelin (EDN-1) - using enzyme immunoassay kit (ELISA) for the quantification in vitro EDN-1 in human serum. Evaluation kit for using enzyme immunoassay technique (ELISA) for the quantitative in vitro determination of ICAM-1 and VCAM-1 in human serum. The results of analyzes are expressed in ng/ml.

Interleukin-6 (IL-6) - Evaluation kit for using enzyme immunoassay technique (ELISA) for the quantitative determination of IL-6 in vitro in human serum. The results of analyzes for IL-6 are expressed in ng/ml.

Oral Glucose Tolerance Test OGTT (in mg/dL). A standard anhydrous glucose load will be administered and evaluation of Oral Glucose Test Tolerance (OGTT) after consumption of a high sugar load.

Profile Evaluation of leukocyte gene expression through nutrigenomics study after consumption capsules containing standardized amount of yerba mate. The genes involved in lipid metabolism are isolated, identified and quantitated by real-time PCR technique. The results are expressed according to the identification and the number of genes.

Karimi Sater Gebara

Master

Institut National de la Recherche Agronomique

Subjects will drink 1000ml/day of yerba mate tea for 8 weeks.

Subjects will drink 1000ml/day of green tea for 8 weeks.

Subjects will drink 1000ml/day of apple tea for 8 weeks.

Dyslipidemia

Inflammation

Obesity

Before and after 8 weeks, serum lipids, C-reactive protein and fibrinogen will be measured. They will also be tested for glycemia, insulin, aminotransferases, bilirubin. Anthropometric measurements will be also performed at week 0 and 8. The subjects will receive instructions to maintain their usual dietary intake and normal physical activity.

yerba/antioksidansi

Yerba Mate (Ilex Paraguariensis A.St.-Hil.): Assessment of Cardiovascular Health

Cardioprotective Effects of Green Tea Versus Maté Intake

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