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Stranica 1 iz 27 rezultatima
Inhibition of Paf-acether-induced edema of the rat's paw.
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Three classes of drugs were found, after their i.p. administration, to inhibit Paf-acether-induced edema of the rat's paw. These were beta-adrenergic agonists (isoproterenol, salbutamol), alpha-adrenergic antagonists (prazosin, ergotamine, yohimbine, phenoxybenzamine), and calcium entry blockers
The role of sympathetic nervous system in the development of neurogenic pulmonary edema in spinal cord-injured rats.
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The pronounced activation of sympathetic nervous system is a necessary prerequisite for the development of neurogenic pulmonary edema (NPE) in rats with balloon compression of spinal cord. In this study we examined whether this is a consequence of rapid activation of spinal pathways leading to
Effect of clonidine on experimental brain edema in the rat.
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Several experimental brain edema models are currently available for drug evaluation. Brain edemas are essentially vasogenic and/or cytotoxic, and eicosanoids are involved in the development of these edemas. Thus, a new model developed in our laboratory, which was obtained by phospholipase A2
Pharmacological study of edema induced by venom of the snake Bothrops asper (terciopelo) in mice.
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The effect of several drugs on the edema-forming activity of Bothrops asper venom was studied plethysmographically using the mouse foot pad assay. Bothrops asper venom induced a dose-dependent edema which developed rapidly and peaked 1 hr after envenomation. Incubation of venom with EDTA before
A pharmacologic analysis of the action of platelet-activating factor in the induction of hindpaw edema in the rat.
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Platelet-activating factor (PAF), a phospholipid product of neutrophils, alveolar macrophages, monocytes, and platelets and an important mediator of inflammatory reactions, was studied for its ability to evoke hindpaw edema in the rat. PAF caused edema, peaking at 1 hr and gradually declining over
[Inhibitory effects of clonidine on edema formation after thermal injury in mice and rats].
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Clonidine 1 mg/kg ip given before thermal injury significantly inhibited the edema formation in mice and rats during the early stage of burn. Clonidine 0.1 mg/kg ip gave no such effect, but it became effective after being administrated via icv. The inhibitory effects of clonidine on edema formation
Alpha-adrenergic blockade in preventing posttransplant edema of lung allograft.
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Effect of alpha-adrenergic blockers on pulmonary edema in lung transplantation was studied with a rat model of syngeneic left lung transplantation. Prior to harvesting, 0.1 mg of Prazosin or 0.4 mg of Yohimbine was given to the donor. Pulmonary and systemic hemodynamics were measured under the right
Studies on epinephrine-induced lung edema in the rat. I. Selective alpha 1-adrenoceptor involvement.
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Phentolamine (Phe) prevents the induction by epinephrine (E: 1800 nmol/kg, i.v.) of lung edema (LE) in urethane-anesthetized and bivagotomized rats in a dose-related manner (from 246 to 3933 nmol/kg, i.v.). Since Phe blocks and E activates both alpha 1- and alpha 2-adrenoceptors, the evidence does
The anti-inflammatory effects of venlafaxine in the rat model of carrageenan-induced paw edema.
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OBJECTIVE
Recently anti-inflammatory effects of antidepressants have been demonstrated. Venlafaxine belongs to newer antidepressants with serotonin norepinephrine reuptake inhibition property. The pain alleviating properties of venlafaxine in different pain models such as neurogenic pain, diabetic
The role of central mechanisms in the anti-inflammatory effect of amitriptyline on carrageenan-induced paw edema in rats.
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OBJECTIVE
The present study was designed to further investigate the effect of amitriptyline, a classical tricyclic antidepressant, on carrageenan-induced paw edema in rats.
METHODS
First, amitriptyline was administered intraperitoneally (i.p.) at doses of 20, 40 and 80 mg kg-1, 30 min before
Central and peripheral anti-inflammatory effects of maprotiline on carrageenan-induced paw edema in rats.
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OBJECTIVE
To explore the site of action of maprotiline, as an atypical antidepressant, on carrageenan-induced paw edema.
METHODS
Male Wistar rats were used.
METHODS
Firstly, the anti-inflammatory effect of systemic maprotiline (12.5, 25 and 50 mg kg(-1)) was assessed using a paw edema model.
Xylazine-induced pulmonary edema in rats.
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Inhibitors of cytochrome P450, such as SK&F 525-A, prolong the duration of xylazine-ketamine anesthesia and cause pulmonary edema (PE) and death in rats. To determine the cause of PE, Sprague-Dawley rats were given a single dose of xylazine (21 mg/kg, im) alone or in combination with ketamine (45
Serotonin-induced paw edema in the rat: pharmacological profile.
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1. Serotonin (5-HT) induced a linear increase in paw weight in rats within 1 hr of an intraplantar injection (50 microliters vol) over a concentration range of 0.005-0.2 mg/ml. At the 0.2 mg/ml concentration, a 16-fold increase in paw weight was observed as compared to saline-injected controls. 2.
Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury.
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OBJECTIVE
To investigate the effect of phenylephrine (an α-adrenergic agonist) on alveolar fluid clearance (AFC) in ventilator-induced lung injury and the possible mechanism involved.
METHODS
A total of 170 male Wistar rats were randomly allocated into 17 groups (n=10) using random number tables.
Adrenoceptor subtypes in the control of burn-induced plasma extravasation.
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Burn trauma is known to induce a significant rise in circulating catecholamine levels and despite catecholamines being potent endogenous vasoactive agents with known actions on microvascular permeability, their effect on burn edema has been poorly investigated. The present study in rats investigated
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