Zhongguo zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban 1998-May

[Clinical study on Zishen Decoction in chronic uric acid nephrosis].

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Q Ni

Z Shi

Q Zheng

ATIK: 11477922

BioSeek: 11477922

Mo kle

urea

triglyceride

uric acid

nephrosis

albumin

creatinine

Abstrè

OBJECTIVE

To observe the ameliorative effect of Zishen Decoction (ZSD) on chronic uric acid nephrosis (CUAN).

METHODS

The 72 CUAN patients were divided into 2 groups: The group with ZSD treatment, the dose of which was 400 ml/d and group with zyloric as the control, the dose of which was 200 mg/d. The treatment lasted for 8 weeks.

RESULTS

The general effective rate of the ZSD group was 92.86%; and that of the control group Was 66.67%. There was significant difference between the two groups (P < 0.01). ZSD treatment reduced the levels of blood uric acid, serum creatinine and blood urea nitrogen and the levels of albumin, beta 2-microglobulin and the activity of N-acetyl-D-glucosaminidase in CUAN (P < 0.01). The levels of triglyceride and total cholesterol decreased and the levels of high density lipoprotein cholesterol increased in the serum of ZSD treated CUAN (P < 0.01).

CONCLUSIONS

ZSD exerted obviously ameliorative effect on renal function in CUAN.