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American Journal of Ophthalmology 2006-Jan

Vitamin E in the treatment of uveitis-associated macular edema.

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Robert B Nussenblatt
Jonghyeon Kim
Darby J S Thompson
Matthew D Davis
Emily Chew
Frederick L Ferris
Ronald Buggage

Mo kle

Abstrè

OBJECTIVE

To investigate whether high-dose alpha-tocopherol (vitamin E) could reduce vision loss and retinal thickening associated with uveitis-associated cystoid macular edema.

METHODS

A double-masked, randomized study.

METHODS

Uveitis patients with macular edema seen at the NIH were randomized and received either 1600 IU/day of vitamin E or placebo for 4 months. Visual acuity and retinal thickening were collected for the efficacy and the safety of the high dose of vitamin E.

RESULTS

Changes in visual acuity and retinal thickening.

CONCLUSIONS

Four-month oral supplementation with 1600 IU/d of vitamin E had no apparent effect on uveitis-associated macular edema or visual acuity in this small study.

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