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Diagnosis of Lung Complication After Allo-HSCT by Multiple Parameter System Through BAL

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一) Adult patients with hematology disease under allo-HSCT at any phase of treatment are enrolled according to the following criteria: 1. lung infiltration detection at computed tomography (CT) scan. 2. Patients with fever, cough, respiratory symptoms. According to the investigators, the patients

The Effectiveness of Pleuran in Treatment of Acute Gastroenteritis in Children

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Study design: This will be a randomized, fully-blind, placebo-controlled trial, with allocation 1:1. Study population: Children aged 13- 120 months, hospitalized or requiring a visit to the emergency department due to acute gastroenteritis (AGE) lasting at least 24 h, but no longer than 72 h at the

Negative Beta Glucan in ICU Patients

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Entry criteria are: In the ICU for >2 days AND systemic antibiotics >2 days OR central venous catheter for >days AND at least two of the following: total parenteral nutrition, dialysis, surgery, pancreatitis, receipt of corticosteroids, receipt of other immunosuppressive agents. In addition,

Empirical Versus Preemptive Antifungal Therapy

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OBJECTIVES: Primary - To compare empirical approach (i.e., fever driven) versus preemptive approach (i.e., diagnostic driven), for starting antifungal therapy with caspofungin acetate, in patients with acute myeloid leukemia or myelodysplastic syndrome who are starting chemotherapy (for attaining

Validation of an Index of Neutropenia (D-index) in Febrile Neutropenic Cancer Patients

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Neutropenia is a major risk factor for invasive fungal infections, particularly those caused by moulds, such as Aspergillus spp., Fusarium spp. and the Zygomycetes. Among neutropenic patients, these invasive mould infections (IMI) occur almost exclusively in patients with profound neutropenia (<100

Caspofungin or Micafungin as Empiric Antifungal Therapy for Persistent Fever and Neutropenia

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Objectives This retrospective cohort analysis of converting from caspofungin to micafungin as empiric antifungal therapy for cancer patients who are persistently febrile and neutropenic after receiving broad spectrum antibiotics at Brigham & Women's Hospital / Dana Farber Cancer Institute (BWH/DFCI)

Efficacy and Safety Study of Soluble Beta-1,3/1,6-Glucan in Thermal Burns

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In severe cases, burn patients commonly exhibit a clinical picture of systemic inflammation with a variety of manifestations ranging from the presence of tachycardia, tachypnea, fever and leukocytosis, and may progress to refractory hypotension. Shock and multiple organ system dysfunction may

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