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antiarthritic/nausea
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DAB486IL-2 fusion toxin in refractory rheumatoid arthritis.
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OBJECTIVE
To evaluate the safety and antiarthritic effects of DAB486IL-2. This agent is a fusion toxin and the product of a synthetic gene, engineered by replacing the codons for the receptor-binding domain of diphtheria toxin (DT) with the codons for human interleukin-2 (IL-2). DAB486IL-2 targets
In silico design of colchicine-based bioisosteric inhibitors of tubulin for the treatment of rheumatoid arthritis.
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The super-saturation of serum with monosodium urate due to hyperuricemia is the core metabolic disorder of rheumatoid arthritis. When the serum urate concentration is ≥7 mg/dl, this results in the crystallization of monosodium urate in serum at body temperature (37˚C/98.6˚F). Colchicine (COL) is
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