antidiarrheals/seizures

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[Seizures and upper digestive hemorrhage associated with antidiarrheal treatment with activated coal].

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Effects of lidamidine hydrochloride (WHR-1142A), a novel antidiarrheal agent on the cardiovascular and central nervous systems.

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1-(2,6-Dimethylphenyl)-3-methylamidinourea hydrochloride (WHR-1142A, lidamidine hydrochloride) has been reported to be a potent antidiarrheal agent in laboratory animals. This study defines its effects on the cardiovascular and central nervous systems. At doses greater than 1 mg/kg i.v., WHR-1142A

[Studies on the CNS activity profile of thalidomide analogs (author's transl)].

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CNS activity of thalidomide was compared with that of 5 analogs modified in the phthalimide or 2,6-dioxopiperidine moiety. All compounds had a qualitatively comparable profile of CNS-depressant actions. In low dosages spontaneous motor activity was depressed, threshold of barbiturate anaesthesia was

Loperamide-Induced Torsades de Pointes: A Case Series.

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BACKGROUND Loperamide is an over-the-counter, inexpensive, antidiarrheal opioid that can produce life-threatening toxicity at high concentrations. CASE REPORT 1: A 28-year-old man with a history of depression and substance abuse disorder (SUD) presented to the emergency department (ED) with

A Unique Interplay of Multiple Predisposing Factors Culminating in a Catastrophic QT Prolongation

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Implantable cardioverter-defibrillators (ICDs) are used in patients without a reversible cause for long QT syndrome (LQTS) and secondary prevention in patients with LQTS-associated sudden cardiac arrest. We present a female patient with multiple reversible factors for QT prolongation, including the

Black henbane and its toxicity - a descriptive review.

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Black henbane (BH) or Hyoscyamus niger, has been used as a medicine since last centuries and has been described in all traditional medicines. It applies as a herbal medicine, but may induce intoxication accidentally or intentionally. All part of BH including leaves, seeds and roots contain some

Chemistry and biology of the genus Voacanga.

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BACKGROUND Herbal remedies have been employed for the treatment and management of various ailments since the beginning of human civilization. Voacanga is an extensive genus of the family Apocynaceae and consists of small trees inhabiting the tropical and subtropical regions of Africa. Voacanga

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