arthritis/hypoxia

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Pharmaceutical composition including an HIF-2 alpha inhibitor as an active ingredient for preventing or treating arthritis

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This is a National Phase Application filed under 35 U.S.C. .sctn.371 as a national stage of International Application No. PCT/KR2010/005889, filed Aug. 31, 2010, claiming the benefit from Korean Patent Application No. 10-2010-0047485, filed May 20, 2010, the entire content of each of which is hereby

Substituted 5-membered ring compounds and their use

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This application is a U.S. National Stage application of co-pending PCT application PCT/GB2004/002755, filed Jun. 24, 2004, which claims the priority of Great Britain Patent Application No. 0315111.5, filed Jun. 27, 2003. These applications are incorporated herein by reference in their

Method of combatting osteoporosis in mammalian subjects, utilizing organic boron compounds

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for preventing and/or treating osteoporosis and other disease states in animal subjects, utilizing organic boron compounds. 2. Description of the Related Art The adult skeleton is composed of 80% cortical

Methods of treatment

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FIELD Provided herein are aldehyde compounds for use in treating diseases such as pulmonary fibrosis, hypoxia, and connective tissue and autoimmune disease such as scleroderma, lupus, arthritis and related conditions in a mammal. BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a deadly lung

Methods of treatment

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Potent LNA oligonucleotides for the inhibition of HIF-1A expression

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FIELD OF THE INVENTION The present invention provides compositions and methods for modulating the expression of HIF-1a. In particular, this invention relates to LNA oligonucleotides, which are specifically hybridisable with nucleic acids encoding HIF-1a. The LNA oligonucleotides have been shown to

Potent LNA oligonucleotides for the inhibition of HIF-1A expression

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Potent LNA oligonucleotides for the inhibition of HIF-1a expression

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Potent LNA oligonucleotides for the inhibition of HIF-1a expression

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This application is a divisional of U.S. patent application Ser. No. 11/271,686, filed on Nov. 9, 2005, which claims the benefit of U.S. Provisional Patent Application No. 60/626,563, filed Nov. 9, 2004; U.S. Provisional Patent Application No. 60/647,186, filed Jan. 25, 2005; U.S. Provisional Patent

Substituted saturated aza heterocycles as inhibitors of nitric oxide synthase

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CROSS REFERENCE TO RELATED APPLICATION The present invention is based on, and claims priority from 60/008,390, filed Dec. 8, 1995. BACKGROUND OF THE INVENTION This application is directed to inhibitors of nitric oxide synthase, and in particular substituted azacycle derivatives. Nitric Oxide in

Cyclic amidine analogs as inhibitors of nitric oxide synthase

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BACKGROUND OF THE INVENTION This application is directed to inhibitors of Nitric oxide synthase, and in particular cyclic amidines. Nitric Oxide in Biology. The emergence of nitric oxide (NO), a reactive, inorganic radical gas as a molecule contributing to important physiological and pathological

Aryloxy phenoxy acrylic compound having HIF-1 inhibition activity, method for preparing same, and pharmaceutical composition containing same as an active ingredient

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CROSS-REFERENCES TO RELATED APPLICATION This patent application is a 371 of PCT/KR2011/007710, filed on Oct. 17, 2011, which claims the benefit of Korean Patent Application No. 10-2010-0102661, filed on Oct. 20, 2010, the contents of each of which are incorporated herein by reference. BACKGROUND OF

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