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arthritis/lafyèv

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Composition for treating arthritic disorder

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TECHNICAL FIELD The present invention relates to compositions and methods for treating a joint disease, including veterinary applications. BACKGROUND For example, articular cartilage is hyaline cartridge that is composed of a small number of cells, collagenous extracellular matrix, abundant
BACKGROUND OF THE INVENTION The present invention is novel compounds which are 3,5-di-tertiary-butyl-4-hydroxyphenyl substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and
BACKGROUND OF THE INVENTION The present invention is novel compounds which are 3,5-di-tertiary-butyl-4-hydroxyphenyl substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and
BACKGROUND OF THE INVENTION The present invention is novel compounds which are 3,5-di-tertiary-butyl-4-hydroxyphenyl substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoes, and 1,2,4-triazoles, and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and

2-substituted-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents

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BACKGROUND OF THE INVENTION The present invention is novel compounds which are 2-substituted-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now

2-substituted amino-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines as antiinflammatory agents

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BACKGROUND OF THE INVENTION The present invention is novel compounds which are 2-substituted amino-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds
BACKGROUND OF THE INVENTION The present invention is a novel compound which is a thiadiazole or oxadiazole analog of a fenamic acid having a substituted hydroxamate side chain and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use thereof

2-substituted amino-4, 6-di-tertiary-buthyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents

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BACKGROUND OF THE INVENTION The present invention is novel compounds which are 2-substituted amino-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds

2-carbonyl substituted-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents

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BACKGROUND OF THE INVENTION The present invention is novel compounds which are 2-substituted-5-hydroxy-1,3-pyrimidine derivatives and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor, where a carbonyl group links the pyrimidine

Substituted heteroaryl analogs of 4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents

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BACKGROUND OF THE INVENTION The present invention is novel compounds which are 4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidine substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical

Derivatives of 3-hydroxyazabenzo(beta)thiophene useful as 5-lipoxygenase inhibitors

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BACKGROUND OF THE INVENTION This invention relates to 3-hydroxyazabenzothiophenes having the 2-position substituted with an optionally substituted aryl, aralkyl, alkyl, or alkenyl group, for example, 3-acetyloxy-7-aza-2-phenyl-benzo[b]thiophene. These novel azabenzothiophenes are found to be either

Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors

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BACKGROUND OF THE INVENTION This invention relates to 3-hydroxyazabenzothiophenes having the 2-position substituted with an optionally substituted aryl, aralkyl, alkyl, or alkenyl group, for example, 3-acetyloxy-7-aza-2-phenyl-benzo[b]thiophene. These novel azabenzothiophenes are found to be either

Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors

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BACKGROUND OF THE INVENTION This invention relates to 3-hydroxyazabenzothiophenes having the 2-position substituted with an optionally substituted aryl, aralkyl, alkyl, or alkenyl group, for example, 3-acetyloxy-7-aza-2-phenyl-benzo[b]thiophene. These novel azabenzothiophenes are found to be either

Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors

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FIELD OF INVENTION The present invention relates to acetylenic aryl sulfonate hydroxamic acids which act as inhibitors of TNF-.alpha. converting enzyme (TACE) and matrix metalloproteinases (MMP), to processes for the preparation of such compounds, and to pharmaceutical compositions comprising such

Acetylenic aryl sulfonate hydroxamic acid TACE and matrix metalloproteinase inhibitors

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FIELD OF INVENTION The present invention relates to acetylenic aryl sulfonate hydroxamic acids which act as inhibitors of TNF-.alpha. converting enzyme (TACE) and matrix metalloproteinases (MMP), to processes for the preparation of such compounds, and to pharmaceutical compositions comprising such
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