arthritis/proline

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Incorporation of 3H-proline into hyaline articular cartilage. An autoradiographic study in rats with and without adjuvant-induced arthritis.

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The incorporation of 3H-proline into the hyaline articular cartilage of rats with and without adjuvant-induced arthritis was investigated 1 h after the intravenous injection of radioactive proline. In the control animals, silver grains were present predominantly over the chondrocytes at all times;

An immunocytochemical study of the distribution of proline-4-hydroxylase in normal, osteoarthritic and rheumatoid arthritic synovium at both the light and electron microscopic level.

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The monoclonal antibody 5B5 reacts with the beta subunit of proline-4-hydroxylase, the enzyme which catalyses the formation of 4-hydroxyl proline in collagen and other proteins with collagen-like amino acid sequences. This study aims to assess the production and tissue distribution of this enzyme in

Salivary acidic proline-rich proteins in rheumatoid arthritis.

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In an ongoing attempt to investigate qualitative salivary parameters in diseases affecting salivary glands, patients with rheumatoid arthritis (RA) were examined. Patients were selected from the Oslo RA register for the present study if they fulfilled the following criteria: age 52-74 years, disease

Increased protocollagen proline hydroxylase activity in synovial tissue in rheumatoid arthritis.

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Effects of bee venom on protease activities and free radical damages in synovial fluid from type II collagen-induced rheumatoid arthritis rats.

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The effect of bee venom acupuncture (BVA) (api-toxin) on the development of type II collagen (CII)-induced arthritis (CIA) in rats has been studied. We have compared the levels of activity of a comprehensive range of cytoplasmic, lysosomal and matrix protease types, together with the levels of free

Non-target metabonomic method provided new insights on the therapeutical mechanism of Gancao Fuzi decoction on rheumatoid arthritis rats.

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Gancao Fuzi decoction (GFD) is a classic Chinese medicine formula for the treatment of rheumatic and rheumatoid arthritis. The main active components of GFD are alkaloids, flavonoids and saponins. This study aimed to clarify the pharmacodynamic effects of the active components in GFD and investigate

Penicillamine in rheumatoid arthritis. Connective tissue changes and alterations in serum copper and phase reactants in relation to clinical improvement.

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Thirteen patients, aged 27 to 70 years, with definite or classical rheumatoid arthritis were treated with penicillamine for six months. Skin biopsies and blood samples were compared with a clinical evaluation before and after therapy. The analyses of the skin included determinations of total

Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography.

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As dysregulation of matrix metalloproteinase (MMP) activity is associated with a wide range of pathophysiological processes like cancer, atherosclerosis, and arthritis, MMPs represent a valuable target for the development of new therapeutics and diagnostic tools. We herein present the chiral pool

CD14 signaling reciprocally controls collagen deposition and turnover to regulate the development of lyme arthritis.

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CD14 is a glycosylphosphatidylinositol-anchored protein expressed primarily on myeloid cells (eg, neutrophils, macrophages, and dendritic cells). CD14(-/-) mice infected with Borrelia burgdorferi, the causative agent of Lyme disease, produce more proinflammatory cytokines and present with greater

Metabolic studies on connective tissue collagens in bone and tendon of adjuvant arthritic rat.

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The metabolic alterations in the matrix of connective tissue collagen were investigated in bone and tendon of rats with adjuvant-induced arthritis. Adjuvant arthritis was induced in rats with the immunization of Freund's adjuvant containing heat-killed Mycobacterium tuberculosis. The changes in the

[Significance of coagulation disorders and inflammatory immune reaction in an infectious model of rheumatoid arthritis. I. Systemic, shock-like coagulopathy and fibrin incorporation as indicators of rheumatoid manifestations in the erysipelas model].

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A combined study employing plethysmographical, scintillation counting and coagulation methods indicates that a coagulation crisis in combination with fibrin overproduction may be an indicator of a beginning arthritis of rheumatoid character. Rats which received a single subcutaneous infection with

In vitro production of collagen by synovial fibroblasts from D-penicillamine-treated arthritic rabbits.

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In order to get further insight into the mechanism of D-penicillamine action on synovial tissue collagen synthesis, fibroblasts derived from drug-treated arthritic rabbits were cultured and labelled with radioactive proline. No evident correlation was found between the amount of newly synthesized

Characteristics of rheumatoid arthritis patients with self-reported sicca symptoms: evaluation of medical, salivary and oral parameters.

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OBJECTIVE To examine the prevalence of sicca symptoms in rheumatoid arthritis (RA)-patients, and to evaluate medical, salivary, and oral parameters in matched subgroups of patients with and without sicca symptoms as well as in healthy controls. METHODS The prevalence of self-reported sicca symptoms

Skin collagen biosynthesis in patients with rheumatoid arthritis treated with D-penicillamine.

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Collagen biosynthesis was measured in skin biopsies taken from 13 patients with rheumatoid arthritis before and after at least 6 months' continuous treatment with D-penicillamine, 1.0 g/day. There was a significant 36% reduction in mean collagen biosynthesis (p less than 0.0125) as assayed by

Influence of prostaglandins E1 and E2 on collagen metabolism in adjuvant induced arthritis.

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In rats with adjuvant induced arthritis, the ihnfluence of PGE1 and PGE2 on collagen metabolism was investigated after an injection of 3H-proline, both the specific and total radioactivity of 3H-ydroxyproline being determined in skin collagen fractions and in urine. In untreated animals with

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