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Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents.
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In this study, we synthesized some natural and semi-synthetic prenyloxyphenylpropanoids (e.g., acetophenones, benzoic and cinnamic acids, chalcones, and coumarins), and we assessed their in vivo neuroprotective activity, using the mouse maximal electroshock-induced seizure model (MES test).
Novel Mannich-bases as Potential Anticonvulsants: Syntheses, Characterization and Biological Evaluation.
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BACKGROUND
Mannich bases are known to be an important pharmacophore or bioactive leads in the synthesis of various potential agents that have a variety of therapeutic activities like anticancer, antipsychotic, anticonvulsant, antimalarial, anti-inflammatory, antibacterial and so forth. Thus, in the
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