chemotherapy/infarction

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Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators

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CROSS REFERENCE TO RELATED APPLICATIONS This application is a national phase of International Application No. PCT/US2014/027450 filed on Mar. 14, 2014, which claims the benefit of U.S. Provisional Application No. 61/785,478 filed on Mar. 14, 2013, each of which are incorporated herein by reference

Medium-chain length fatty acids and glycerides as nephroprotection agents

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FIELD OF THE INVENTION The present invention relates to protection against renal failure progression in chronic kidney diseases. This includes the treatment of kidney diseases associated with nephrectomy, renal fibrosis, glomerular sclerosis, and end-stage renal disease. This also includes

Benzimidazolone derivatives as CB2 receptor ligands

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BACKGROUND OF THE INVENTION This invention relates to benzimidazolone derivatives. These compounds have selective cannabinoid(CB)2 receptor binding activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives for the

Sulfonyl benzimidazole derivatives

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BACKGROUND OF THE INVENTION This invention relates to sulfonyl benzimidazole derivatives. These compounds have selective cannabinoid (CB)2 receptor agonistic activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives

Human G-protein coupled receptor

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The present invention relates to novel identified polynucleotides, polypeptides encoded by them and to the use of such polynucleotides and polypeptides, and to their production. More particularly, the polynucleotides and polypeptides of the present invention relate to a G-protein coupled receptor

Antibodies immunospecific for a novel human G-protein coupled receptor family

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Pharmaceutically acceptable salts of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide

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BACKGROUND OF THE INVENTION The present invention relates to pharmaceutically acceptable salts of an amide substituted indazole which are inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), previously known as poly(ADP-ribose)synthase and poly(ADP-ribosyl)transferase. The compounds of the

Activated protein C variants with normal cytoprotective activity but reduced anticoagulant activity

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FIELD OF THE INVENTION The present invention relates to variants (mutants) of recombinant protein C and activated protein C, an enzyme that normally has anti-thrombotic, anti-inflammatory, and anti-apoptotic activities. The recombinant activated protein C mutants of the invention have markedly

Activated protein C variants with normal cytoprotective activity but reduced anticoagulant activity

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