contracture/fatigue

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Effects of fatigue on depolarization- and caffeine-induced contractures of skinned fibres.

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OBJECTIVE Fatigue has been shown to cause intrinsic alterations in sarcoplasmic reticulum (SR) Ca2+ release. METHODS In this investigation, frog semitendinosus muscles were stimulated to fatigue, in vitro (80 Hz, 100 ms, 1 train s-1, 5 min). Immediately after stimulation, single fibres were removed

[Contracture caused by potassium. Amplitude of the mechanical manifestation in striated muscles of Rana esculenta after complete fatigue].

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Effects of 17beta-estradiol on tension responses and fatigue in the skeletal twitch muscle fibers of frog.

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The effects of 17beta-estradiol (10(-5) M), an active estrogen, on the tension and fatigue responses of single fiber or fiber bundle prepared from frog skeletal muscle were investigated. The administration of 17beta-estradiol caused a transient potentiation of tetanus tension by field stimulation at

Decrease in force potentiation and appearance of alpha-adrenergic mediated contracture in aging rat skeletal muscle.

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The effect of increasing age on contractile performance and catecholamine receptor activity was investigated in a distal, predominantly fast twitch oxidative glycolytic (FOG) muscle from the plantar surface of the rat hindfoot. The ability of the flexor digitorum brevis (FDB), isolated from

In vitro diagnosis of malignant hyperthermia: influence of electrical stimulation on the contracture response to caffeine.

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We have examined the influence of electrical stimulation on caffeine-induced tension generation during contracture testing used to diagnose malignant hyperthermia. The cumulative contracture response to caffeine was compared in pairs of morphologically comparable muscle bundles obtained from the

Fatigue-induced alterations in Ca2+ and caffeine sensitivities of skinned muscle fibers.

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The purpose of this investigation was to examine the Ca2+ and caffeine sensitivities of skinned skeletal muscle fibers after fatigue. Single frog semitendinosus fibers were chemically skinned in either a rested state or after tetanic contractions (80 Hz, 100 ms) evoked at 2 s-1 for 5 min. This

Differential activation of myofibrils during fatigue in phasic skeletal muscle cells.

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In fatigued muscles the T-system is swollen; thus the action potential may fail to travel along the T-system or the T-tubule terminal cisternae signal may fail to bring about TC Ca2+ release. This would lead to a decrease in the number of myofibrils activated and in force development, but if fatigue

Myofibrillar fatigue versus failure of activation during repetitive stimulation of frog muscle fibres.

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1. Single fibres isolated from the anterior tibialis muscle of Rana temporaria (temperature, 2-5 degrees C; sarcomere length, 2.10 microns) were fatigued using two separate protocols that led to different degrees of depression of tetanic force. Under control conditions the fibre was stimulated to

Dihydropyridine effects on skeletal muscle fatigue.

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1. The purpose of this investigation was to determine if alterations in extracellular calcium (Ca2+) influx by the dihydropyridine derivatives Bay K 8644 and nifedipine affected skeletal muscle fatigue. 2. Tetanic contractions (80 Hz, 100 msec) of frog sartorius muscles were evoked every sec for 3

H2O2 activates ryanodine receptor but has little effect on recovery of releasable Ca2+ content after fatigue.

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We studied whether hydrogen peroxide (H(2)O(2)) at fatigue. Exposure of rabbit or frog skeletal muscle ryanodine receptors to 10 microM H(2)O(2) enhanced channel activity in

Muscle fatigue in McArdle's disease studied by 31P-NMR: effect of glucose infusion.

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In muscle phosphorylase deficiency (McArdle's disease) there is an abnormally rapid fatigue during strenuous exercise. Increasing substrate availability to working muscle can improve exercise tolerance but the effect on muscle energy metabolism has not been studied. Using phosphorus-31 nuclear

Angelo Mosso and muscular fatigue: 116 years after the first Congress of Physiologists: IUPS commemoration.

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At the first International Congress of Physiologists in Basel, Switzerland, the Italian physiologist Angelo Mosso (1846-1910) discussed his findings on muscular fatigue while demonstrating the functioning of an ergograph (work recorder). One hundred sixteen years later, Mosso's career, scientific

Potassium and caffeine contractures of mouse muscles before and after fatiguing stimulation.

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To assess the impairment of muscle membrane excitation, excitation-contraction (E-C) coupling, and contractility during muscle fatigue, we monitored the contracture responses of resting and fatigued muscles on exposure to high potassium and caffeine. On exposure to 140 mmol/L potassium, mouse

Properties of caffeine- and potassium-contractures in fatigued frog single twitch muscle fibers.

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The properties of caffeine contracture and potassium contracture in fatigued single fibers were examined in detail using frog semitendinosus muscle, Rana japonica. Fatigue was caused by repetitive stimulation at 2 Hz. The dose-response curve of caffeine contracture in the fatigued fibers was shifted

A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions.

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Episodic ataxia type 1 (EA1) is a human dominant neurological syndrome characterized by continuous myokymia, episodic attacks of ataxic gait and spastic contractions of skeletal muscles that can be triggered by emotional stress and fatigue. This rare disease is caused by missense mutations in the

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