contracture/hyoscine

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Block of the hyoscine-resistant opiate withdrawal contracture of ileum by a new substance P antagonist [D-Arg1,D-Phe5,D- Trp7,9,Leu 11]substance P.

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Model of opiate dependence in the guinea-pig isolated ileum.

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1 Segments of ileum, incubated for 2-24 h at 22 degrees C with normorphine (0.01 - 1.0 muM), in the presence of hexamethonium, contracted when challenged with naloxone (0.03 muM). No response to this dose of naloxone was induced either by incubation in control solution without opiate for 2-24 h or

Clonidine dependence in the guinea-pig isolated ileum.

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1 Compared with the response of preparations incubated in solutions without clonidine, a three to four fold increase in the magnitude of the contracture of the longitudinal muscle to challenge with phentolamine (1.0 mum) was induced by incubating the guinea-pig isolated ileum at 22 degrees C for 24

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