contracture/hypoxia

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Upregulation of interleukin-1β/transforming growth factor-β1 and hypoxia relate to molecular mechanisms underlying immobilization-induced muscle contracture.

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BACKGROUND In this study we investigated the molecular mechanism underlying muscle contracture in rats. METHODS The rats were divided into immobilization and control groups, and soleus muscles of the right and left sides were selected for analyses. RESULTS The levels of CD11b and α-SMA protein,

Sclerema neonatorum and joint contractures at birth as a potential complication of chronic in utero hypoxia.

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Three term neonates presented with an unusual combination of skin changes (sclerema) and joint contractures at birth. In each case a prolonged period of fetal hyporeactivity was reported by the mother. Each child demonstrated a number of clinical findings consistent with chronic fetal hypoxia. Each

Alteration of fetal oxygenation and responses to acute hypoxemia by increased myometrial contracture frequency produced by pulse administration of oxytocin to the pregnant ewe from 96 to 131 days' gestation.

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OBJECTIVE This study examined the effects of increased myometrial contracture frequency from 96 to 131 days' gestation on ovine fetal oxygen transport and physiologic response to acute hypoxemia. METHODS Ten pregnant ewes received either saline solution (control, n = 5) or long-term administration

Therapeutic effect of intra-articular injection of ribbon-type decoy oligonucleotides for hypoxia inducible factor-1 on joint contracture in an immobilized knee animal model.

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BACKGROUND Limited range of motion (ROM) as a result of joint contracture in treatment associated with joint immobilization or motor paralysis is a critical issue. However, its molecular mechanism has not been fully clarified and a therapeutic approach is not yet established. METHODS In the present

Hypoxia-induced epithelial-mesenchymal transition and fibrosis for the development of breast capsular contracture.

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Fibrosis has been considered as a major cause of capsular contracture. Hypoxia has widely emerged as one of the driving factors for fibrotic diseases. The aim of this study was to examine the association between hypoxia-induced fibrosis and breast capsular contracture formation. Fibrosis,

Contractures and increase in internal longitudianl resistance of cow ventricular muscle induced by hypoxia.

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This study was performed to determine whether hypoxia in glucose-free solutions can increase the electrical resistance of intercellular junctions in ventricular muscle. Internal longitudinal resistance (Ri), mechanical tension, and transmembrane action potentials were measured simultaneously in cow

Parallel temperature dependence of contracture-associated enzyme release due to anoxia, 2,4-dinitrophenol (DNP), or caffeine and the calcium paradox.

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Hypothermia during calcium-free perfusion of hearts protects them from injury caused by subsequent calcium repletion at 37 C (calcium paradox). Injury to calcium-free hearts is also associated with contracture caused by anoxia, 2,4-dinitrophenol (DNP), or caffeine. This study was done for the

Hypoxia, calcium, and contracture as mediators of myocardial enzyme release.

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During calcium-free perfusion, anoxic contracture of myocardial cells causes cells to separate at intercalated disks and leads to an energy-independent enzyme release in the absence of active transmembrane calcium fluxes. It is proposed that contracture mediates membrane damage and enzyme release in

Contracture development in anoxia: the importance of asynchrony.

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Several studies have reported a linear correlation between ATP levels, measured on isolated adult heart cells exposed to anoxia, and cellular configuration. The case is presented here for the viewpoint that these results can best be explained by an asynchronous decline in cellular ATP levels. By

Contracture type and fibrosis type of decreased myocardial distensibility. Different changes in elasticity of myocardium in hypoxia and hypertrophy.

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Resting length-tension relationships were measured in rat trabecular muscle strips under control (O2) and contracture (N2) conditions as well as in preparations of Goldblatt II (8-week stage) and control rats. For the evaluation of the diastolic elastic properties, diastolic stress at 1max,

Effects of hypoxia, acidosis, and simulated ischemia on repriming of caffeine contracture in rat myocardium.

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This study was designed to examine the effects of hypoxia, acidosis, glucose-free medium and their combination on contraction and sarcoplasmic reticulum (SR) function in rat ventricular trabeculae. The isometric twitch tension was measured during superfusion with hypoxic (PO2 less than 30 mmHg),

Understanding the temporal relationship of ATP loss, calcium loading, and rigor contracture during anoxia, and hypercontracture after anoxia in cardiac myocytes.

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[Contracture of homothermal muscle in hypoglycemia and hypoxia; a report on the theory of the active muscle relaxation].

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Anoxia, calcium and contracture as mediators of myocardial enzyme release.

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The effect of coronary pressure on contracture and vascular perfusion in the hypoxic isolated rat heart.

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The relationships among coronary perfusion pressure (0-150 cm H2O), ventricular contracture, vascular resistance, and loss of perfusion of subendocardial myocardium were studied in anoxic isolated rat hearts. Coronary flow and myocardial pH and lactate concentrations were measured during 60 minutes,

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