diabetes mellitus type 1/protease

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Anti-inflammatory Therapy to Improve Outcomes After TPIAT

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For patients with severe pancreatitis refractory to medical and endoscopic therapy, total pancreatectomy (TP) with islet autotransplantation (IAT) may be considered. While 90% of TPIAT recipients have some function of the transplanted islet graft, only about 1/3rd come completely off insulin. The

Mixed Meal Test in Type 1 Diabetes on Insulin Pump Therapy: Optimization of Artificial Pancreas

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BACKGROUND: Ideally, optimal treatment of T1DM should achieve near-normal glucose with no hypoglycemias and preserved quality of life. In the clinical arena, even the currently available most complex strategy, i.e. glucose sensor augmented insulin pump therapy, in which patients wear both a pump for

Urine-plasminogen as a Predictor for Development Of Preeclampsia in Pregnant Women With Type 1 Diabetes Mellitus

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Study aim and hypothesis: Aim: To test whether there is a measurable correlation between plasmin/plasminogen, abnormally excreted in the kidneys, and the development of pre-eclampsia in pregnant women with Type 1 diabetes. Hypothesis: 1. The amount of proteases ( plasmin/plasminogen ), excreted in

A Pilot Study of Moderate Hyperbilirubinemia in Type 1 Diabetes Mellitus

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Diabetes mellitus (DM) is associated with a markedly increased risk of both macro- and microvascular disease. Excess pro-oxidants and insufficient antioxidants each contributes to oxidant stress in DM. Oxidant stress induces endothelial dysfunction, a major determinant of vascular damage. In DM,

Study of the Safety and Efficacy of Intravenous Alpha-1 Antitrypsin in Type 1 Diabetes Mellitus

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AAT is a protein produced by the human liver and secreted into the blood circulation. AAT, which belongs to a group of serine protease inhibitors (SERPINS) is an acute stress reactant protein that increases during stress conditions, including inflammation. AAT blocks serine proteases that enhance

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