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diabetes mellitus type 2/vomiting
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Ethynyl derivatives
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The present invention relates to compounds of formula I
##STR00002## wherein Y is C--R.sup.1'; R.sup.1' is hydrogen or halogen; R.sup.1 is hydrogen or halogen; R.sup.2 is hydrogen, lower alkyl or phenyl; R.sup.4 is hydrogen or lower alkyl; or R.sup.2 and R.sup.4 may form together with the
Ethynyl derivatives
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The present invention relates to compounds of formula I
##STR00001## wherein R.sup.1 is lower alkyl; R.sup.2 is phenyl or pyridinyl, wherein the N atom in the pyridinyl group may be in different positions; n is 0, 1 or 2; V/U are independently from each other O or CH.sub.2, wherein V and U cannot be
Ethynyl derivatives
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The present invention relates to compounds of formula I
##STR00001## wherein Y is N or C--R.sup.1'; G is a 5 or 6-membered aromatic or heteroaromatic ring containing 0, 1, 2 or 3 heteroatoms, selected from the group consisting of phenyl, pyridinyl with different N-positions, imidazolyl, pyrazinyl,
Ethynyl derivatives
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This application is a continuation of International Application PCT/EP2015/053785, filed Feb. 24, 2015, which claims benefit of priority to European Application 14156461.7, filed Feb. 25, 2014, each of which is incorporated herein by reference in its entirety.
The present invention relates to
Ethynyl derivatives
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The present invention relates to compounds of formula I
##STR00002## wherein Y is C--R.sup.1; R.sup.1' is hydrogen, F or Cl; R.sup.1 is F or Cl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is phenyl, pyridinyl or isothiazolyl, wherein the N atom in the pyridinyl group may be in different positions,
Ethynyl derivatives
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FIELD OF THE INVENTION
The present invention relates to organic of general formula I that are positive allosteric modulators (PAMs) of metabotropic glutamate receptor 4 (mGluR4). useful for therapy of diseases associated with aberrant functioning of the mGluR4 receptor.
BACKGROUND OF THE
Methods and compositions for the measurement of glucose tolerance
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BACKGROUND OF THE INVENTION
A. Field On The Invention
The present invention relates generally to methods and compositions for measuring glucose tolerance, such as in connection with oral glucose tolerance tests for the diagnosis of diabetes mellitus and other conditions relating to the body's
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