diterpene/obesity

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Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK-Ay mice.

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Terpenoids, which are contained in a large number of dietary and herbal plants, have many biological effects. In this study, the effects of dehydroabietic acid (DAA), a diterpene, on glucose and lipid metabolism were examined using obese diabetic KK-Ay mice. We showed here that DAA treatment

Anti-obesity effect of plant diterpenes and their derivatives: A review.

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Obesity is a medical condition in which excess body fat is accumulated by a combination of excessive food intake, lack of physical activity, and genetic susceptibility. Obesity increases the risk of various diseases and conditions, including cardiovascular diseases, diabetes, cancer, and depression.

A clerodane diterpene inhibit adipogenesis by cell cycle arrest and ameliorate obesity in C57BL/6 mice.

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A clerodane diterpene, 16α-Hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide (compound 1) isolated from Polyalthia longifolia had previously been reported as a new structural class of HMG-CoA reductase inhibitor apart from statins. Statins are known to be anti-adipogenic in nature. The distant

Functional Fungal Endophytes in Coleus forskohlii Regulate Labdane Diterpene Biosynthesis for Elevated Forskolin Accumulation in Roots.

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Coleus forskohlii is a perennial medicinal shrub cultivated mainly for its forskolin content. The plant has been used since ancient times in ayurvedic traditional medicines for the treatment of hypertension, glaucoma, asthma, congestive heart failures, obesity, and cancer. Use of endophytic

Sclareol-loaded lipid nanoparticles improved metabolic profile in obese mice.

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Sclareol is a bioactive hydrophobic diterpene in the essential oil isolated from Salvia sclarea (Fam. Lamiaceae). Sclareol has been widely studied due to its anti-inflammatory and antioxidant effects.The present study aimed to evaluate the effects of

REVIEW: ABIETANE DITERPENES AS POTENTIAL CANDIDATES FOR THE MANAGEMENT OF TYPE 2 DIABETES.

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Diabetes mellitus (DM), being one of the most common metabolic disorders with an elevated morbidity and mortality rate. It is characterised by deficiency in insulin secretion or degradation of secreted insulin. Many internal and external factors such as oxidative stress, obesity and sedentary

α-Glucosidase and Pancreatic Lipase Inhibitory Activities of Diterpenes from Indian Mango Ginger (Curcuma amada Roxb.) and Its Derivatives.

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Enzymatic inhibitions of crude extracts and their constituents from Zingiberaceae against both rat intestinal α-glucosidase and porcine pancreatic lipase were investigated. Structure-activity relationships using their derivatives were also investigated. The rhizomes extract of mango ginger,

The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism.

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Peroxisome proliferator-activated receptor (PPAR) gamma is a nuclear receptor that coordinates carbohydrate and lipid metabolism, and is a therapeutic target for type 2 diabetes. Tanshinone IIA (Tan) is a lipophilic diterpene that is widely used to treat cardiovascular diseases in traditional

PTP1B inhibitory activity of kaurane diterpenes isolated from Siegesbeckia glabrescens.

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Protein tyrosine phosphatase 1B (PTP1B) is considered as a therapeutic target for the treatment of diabetes and obesity. In our preliminary screening study, a MeOH extract of the aerial part of Siegesbeckia glabrescens was found to inhibit PTP1B activity at 30 microg/mL. Bioassay-guided

Polyalthia Clerodane Diterpene Potentiates Hypoglycemia via Inhibition of Dipeptidyl Peptidase 4.

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Serine protease dipeptidyl peptidase 4 (DPP-4) is involved in self/non-self-recognition and insulin sensitivity. DPP-4 inhibitors are conventional choices for diabetic treatment; however, side effects such as headache, bronchus infection, and nasopharyngitis might affect the daily lives of diabetic

The cardioprotective effects of marrubiin, a diterpenoid found in Leonotis leonurus extracts.

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BACKGROUND Leonotis leonurus L. (Lamiaceae) is used as a traditional medicine for a variety of ailments in South Africa. The diterpene marrubiin is the major product constituent in specimens of this plant occurring in South Africa. METHODS Marrubiin isolated from South African specimens of L.

Treatment of db/db diabetic mice with triptolide: a novel therapy for diabetic nephropathy.

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BACKGROUND Current research on the progression of diabetic nephropathy (DN) suggests many important factors; metabolic disturbance, haemodynamic abnormity, chronic inflammation, oxidative stress, innate immune system activation and podocyte lesion. Triptolide, which is active diterpene purified from

Isolation of diacyl glycerol acyl transferase (DGAT) inhibitors from Pachydictyon coriaceum.

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The pharmacological inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) has emerged as a target for the treatment of obesity and type 2 diabetes. Chromatographic analysis of the brown alga, Pachydictyon coriaceum, led to the isolation of diterpene dictyol E and

Kahweol Reduces Food Intake of Caenorhabditis elegans

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The coffee diterpene kahweol may contribute to the anti-obesity effects of coffee, but its physiological effects have yet to be elucidated. Caenorhabditis elegans is used as an animal model in obesity research because its lipid metabolism is conserved in humans. The goal was to investigate

Kahweol Reduces Food Intake of Caenorhabditis elegans

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